Gireesh,G; Dr. Paulose, C S(Cochin University of Science & Technology, January , 2007)
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Abstract:
The present work is to understand the alterations of total Muscarinic and
Muscarinic MI receptors in brain and pancreatic islets of Streptozotocin induced
diabetic rats. The work focuses on the evaluation of the antihyperglycemic activity
of aqueous extracts of Aegle marmelose and Costus pictus leaves in vivo and the
changes in the total Muscarinic and Muscarinic MI receptors during diabetes and
after the treatment with insulin. The insulin secretory activity of Aegle marmelose
and Costus pictus leaf extracts and the effect of cholinergic receptor agonist were
investigated in vitro using rat primary pancreatic islet culture. Muscarinic MI
receptor kinetics and gene expression during diabetes and regulation of insulin
secretion by Aegle marmelose and Costus pie/us leaf extracts will help us to
elucidate the role of Muscarinic and Muscarinic MI receptors in hyperglycemia
and the regulatory activity of these plant extracts on insulin secretion through
Muscarinic receptors.
Description:
Department of
Biotechnology, Cochin University of Science and Technology
Reas Khan, S; Dr. Paulose, C S(Cochin University of Science and Technology, April , 2007)
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Abstract:
The present work is to understand the alterations of total muscarinic.
muscarinic MI and glutamate receptors in the brain regions of pilocarpine induced
epileptic rats. The work focuses on the evaluation of the anti epileptic activity of
extracts of Bacopa monnieri, Bacoside A and Carbamazepine in vivo. The
molecular changes in the muscarinic M I receptors in the pre- and post-treated
epileptic model with Bacopa monnieri, Bacoside A and Carbamazepine were also
studied. These studies will help us to elucidate the functional role of muscarinic
and glutamate receptors in epilepsy.
Description:
Department of Biotechnology, Cochin University of
Science and Technology
Vineetha K.A; Dr. Ajitha, K(Cochin University of Science and Technology, November 6, 2015)
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Abstract:
िशक्षा एवं जागरण के फलस्वरूप आधुिनक समाज म नारी िविभ क्षेतर्ो म
उपलिब्धयाँ हािसल करने लगी है| वह हर क्षेतर् म पुरुष के साथ कंधे से कन्धा िमलाकर
आगे बढ़ने की कोिशश कर रही है| पर िपतृसा भी हर युग म अपना वचर्स्व बनाये
रखने की कोिशश करती आ रही है| वह ी को हमेशा दूसरे दज के नागिरक के रूप म
मानती है| वह नारी की गित पर रोक लगाने का पर्यास करती रहती है क्यिक उसके
स्वाथ की पूित के िलए यह अिनवायर् है| आज़ादी के इतने वषर् बीतने पर भी नारी की
िस्थित म अनेकानेक िवडंबनाय िदखाई पड रही ह| भूमंडलीकरण भी उसे यौन िसबंल
के रूप म पिरवितत कर रहा है|
Ramakrishnan, R; Dr. Manoj Raama Varma; Dr. J. D. Sudha(Cochin University of Science and Technology, July 25, 2014)
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Abstract:
Recent developments on nanostructured conducting polymer-inorganic
composites systems have receieved considerable research interest owing to their
unique synergestic properties compared with their individual bulk counter parts
which make them promising candidates for a broad spectrum of high technological
applications such as in energy conversion, electronic devices, storage, sensors,
actuators, memory devices, and biomedical devices. Nanostructured conducting
polymers possess unique features such as high specific surface area, high charge
carrier concentration, high electrical conductivity, high mechanical flexibility, light
weight, solution processability and printability over a large area which make them
favourable for their high tech applications. Among the conducting polymers,
polyanilline, poly(3,4-ethylene dioxy thiophene), poly(N-vinylcarbzole) are
receiving much importance due to their low cost, environmental stability and
unique doping mechanism. Conversely, semiconducting inorganic metal oxide such
as zinc oxide and titania nanomaterials have emerged as an area of intense research
interest motivated by their potential applications in electronics, non-linear optics,
and magnetic devices due to their low band gap, small crystalline size and unique
opto-electronic properties. In this perspective, studies on the development and
applications of semiconducting polymer-inorganic metal oxide nanocomposite are
interesting since it is expected to exhibit synergistic properties arising from the
molecular level mixing of conducting polymer and inorganic counter parts.
Aswathy, K V; Dr.Rani,Joseph(Cochin University of Science & Technology, September , 2007)
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Abstract:
Various synthesis routes have been developed in recent years for the
preparation of nanoparticles. One of those methods is polymer induced
crystallization. The first objective of the present work was to prepare nano ZnO
powder by polymer induced crystallization in chitosan solution and to
characterize the material using different techniques like TEM, SEM, XRD,
FTLR, UV spectroscopy, TGA, DSC etc.The second object of the study is to prepare composites using nano ZnO. It
has been undertaken to explore the potential of nano ZnO as reinforcement in
engineering as well as commodity thermoplastics to widen their application
spectra. We selected three engineering thermoplastics like [poly ethylene
terephthalate, polyamide 6, and polycarbonate] and three commodity plastics
like [polypropylene, high density polyethylene, and polystyrene] for the study.
To date one of the few disadvantages associated with nanoparticle incorporation
has concerned toughness and impact performance. Modification of polymers
could reduce impact performance. The present study also focused on whether
nano ZnO can act as a modifier for thennoplastics, without sacrificing their
impact strength.
Description:
Department of Polymer Science and Rubber Technology,
Cochin University of Science and Technology
Sasidharan, K K; Dr. Thomas, Kurian; Dr. Rosamma, Alex(Cochin University of Science And Technology, February , 2014)
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Abstract:
Sensitisation of natural rubber latex by addition of a small quantity of
an anionic surfactant prior to the addition of a coacervant results in quick
coagulation. The natural rubber prepared by the novel coagulation method
shows improved raw rubber characteristics, better cure characteristics in
gum and carbon black filled compounds and improved mechanical
properties as compared to the conventionally coagulated natural rubber.
Compounds based on dried masterbatches prepared by the incorporation of
fluffy carbon black in different forms of soap sensitised natural rubber
latices such as fresh latex, preserved field latex, centrifuged latex and a
blend of preserved field latex and skim latex show improved cure
characteristics and vucanizate properties as compared to an equivalent
conventional dry rubber-fluffy carbon black based compound.
The latex masterbatch based vulcanizates show higher level of
crosslinking and better dispersion of filler. Vulcanizates based on fresh
natural rubber latex- dual filler masterbatches containing a blend of carbon
black and silica prepared by the modified coagulation process shows very
good mechanical and dynamic properties that could be correlated to a low
rolling resistance. The carbon black/silica/nanoclay tri-filler - fresh natural
rubber latex masterbatch based vulcanizates show improved mechanical
properties as the proportion of nanoclay increased up to 5 phr.
The fresh natural rubber latex based carbon black-silica masterbatch/
polybutadiene blend vulcanizates show superior mechanical and dynamic
properties as compared to the equivalent compound vulcanizates prepared
from the dry natural rubber-filler (conventional dry mix)/polybutadiene blends
Description:
Department of Polymer Science and Rubber Technology
Cochin University of Science and Technology
Joshi, K K; Dr.Parameswaran Pillai, P(Cochin University Of Science And Technology, November , 1990)
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Abstract:
The present work "Nature and Ecological Significance of Nutrient
Regeneration in different Prawn Culture Fields" was undertaken to understand
the seasonal variation of nutrients, nutrient cycling and primary productivity
of the prawn culture systems. The main emphasis was to find the qualitative
and quantitative estimates of distribution of total phosphorus, inorganic
phosphorus, organic phosphorus, total nitrogen and nitrogen fractions in the
water. The effect of nutrient cycling on primary productivity and concentration
of metals also form one part of the study.
The entire thesis comprise of only one major chapter with subchapters
such as, Introduction (I), Review of Literature (2), Material and
Methods (3), Results (14), Discussion (5), Executive Summary (6) and Biblio~
graphy (7)
Description:
Centre of Advanced Studies in Mariculture,Cochin University Of Science And Technology
Radhakrishnan, P; Dr.Sathianandan, K(Cochin University of Science and Technology, April 30, 1985)
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Abstract:
Laser-induced damage is the principal limiting constraint in the design and operation of high-power laser systems used in fusion and other high-energy laser applications. Therefore, an understanding of the mechanisms which cause the radiation damage to the components employed
in building a laser and a knowledge of the damage threshold of these materials are of great importance in designing a laser system and to operate it without appreciable degradation in performance. This thesis, even though covers three distinct problems for investigations using a dye Q-switched multimode Nd:glass laser operating at 1062 nm and emitting 25 ns (FWHM) pulses, lays its main thrust on damage threshold studies on thin films. Using the same glass
laser two-photon excited fluorescence in rhodamine 6G and generation and characterisation of a carbon plasma have also been carried out. The thesis is presented in seven chapters.
Description:
Department of Physics, Cochin university of Science and Technology
Radhakrishnan, P; Dr.Sathianandan, K(Cochin University Of Science And Technology, April 30, 1985)
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Abstract:
Laser-induced damage is the principal limiting
constraint in the design and operation of high-power laser
systems used in fusion and other high-energy laser applications.
Therefore, an understanding of the mechanisms
which cause the radiation damage to the components employed
in building a laser and a knowledge of the damage threshold
of these materials are of great importance in designing a
laser system and to operate it without appreciable degradation
in performance. This thesis, even though covers
three distinct problems for investigations using a dye
Q-switched multimode Nd:glass laser operating at 1062 nm
and emitting 25 ns (FWHM) pulses, lays its main thrust on
damage threshold studies on thin films. Using the same glass
laser two-photon excited fluorescence in rhodamine 6G and
generation and characterisation of a carbon plasma have also
been carried out.
Description:
Department of Physics, Cochin University Of Science And Technology
Archana, R; Dr. R Gopikakumari; Dr. A Unnikrishnan(Cochin University of Science and Technology, March 12, 2015)
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Abstract:
Modeling of chaotic systems, based on the output time series, is quite
promising since the output often represents the characteristic behaviour of
the total system. It has been an interesting topic for researchers over the past
few years. So far, some methods are developed for the identification of
chaotic systems. Because of the intense complexity of chaotic systems, the
performance of existing algorithms is not always satisfactory. Application of
chaotic system theory to socially relevant problems like environmental
studies is the need of the hour Neural networks have the required self-learning capability to tune the
network parameters (i.e. weights) for identifying highly non-linear and
chaotic systems. In the present work, effectiveness of modeling a chaotic
system using dynamic neural networks has been demonstrated. From the rich
literature available for non-linear modeling with neural networks, the
Recurrent Neural Network (RNN) structure is selected. The Extended
Kalman Filter (EKF) algorithm is used to train the RNN. Further, the
Expectation Maximization algorithm is used to effectively arrive at the initial
states and the state covariance. Particle filter algorithm with its two important
variants namely Sampling Importance Resampling (SIR) and Rao
Blackwellised algorithms are also used for training the given RNN. Four
standard chaotic systems, Lorenz, Rossler, Chua and Chen, are modelled
with the three algorithms. The best algorithm is found to be EKF-EM based
on the least mean square error criterion. Validation of RNN model with EKFEM
algorithm is done in time domain by Estimation of embedding
dimension, Phase plots, Lyapunov Exponents, Kaplan -Yorke dimension and
Bifurcation diagrams. Analysis of the chaotic systems is also performed in
the transform domain using Fourier, Wavelet and Mapped Real Transforms.
viii
Natural chaotic systems are analyzed based on the selected model structure
and training algorithm, taken for analysis. Sunspot, Venice Lagoon and
North Atlantic oscillations are the three of the natural chaotic systems
modelled with the selected RNN model structure and EKF-EM algorithm.
Anitha, M; Dr. Paulose, C S(Cochin University of Science and Technology, July , 2012)
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Abstract:
This thesis Entitled Neuronal degeneration in streptozotocin induced diabetic rats: effect of aegle marmelose and pyridoxine in pancreatic B cell proliferation and neuronal survival. Diabetes mellitus, a chronic metabolic disorder results in neurological dysfunctions and structural changes in the CNS. Antioxidant therapy is a challenging but necessary dimension in the management of diabetes and neurodegenerative changes associated with it. Our results showed regional variation and imbalance in the expression pattern of dopaminergic receptor subtypes in diabetes and its role in imbalanced insulin signaling and glucose regulation. Disrupted dopaminergic signaling and increased hyperglycemic stress in diabetes contributed to the neuronal loss. Neuronal loss in diabetic rats mediated through the expression of pattern of GLUT-3, CREB, IGF-1, Akt-1, NF,B, second messengers- cAMP, cGMP, IP3 and activation of apoptotic factors factors- TNF-a,caspase-8. Disrupted dopaminergic receptor expressions and its signaling in pancreas contributed defective insulin secretion in diabetes. Activation of apoptotic factors- TNF- a,caspase-8 and defective functioning of neuronal survival factors, disrupted second messenger signaling modulated neuronal viability in diabetes. Hyperglycemic stress activated the expression of TNF-a,caspase-8, BAX and differential expression of anti oxidant
enzymes- SOD and GPx in liver lead to apoptosis. Treatment of diabetic rats with insulin, Aegle marmelose and pyridoxine significantly reversed the altered dopaminergic neurotransmission, GLUT3, GLUT2, IGF-1 and second messenger signaling. Antihyperglycemic and antioxidant activity of Aegle marmelose and pyridoxine enhanced pancreatic B cell proliferation, increased insulin synthesis and secretion in diabetic rats. Thus our results conclude the neuroprotective and regenerating ability of Aegle marmelose and pyridoxine which in turn has a novel therapeutic role in the management of diabetes.
Description:
Center for neuroscience, Department of Biotechnology, Cochin University of Science and Technology