Leena, R; Dr.Girish Kumar, K(Cochin University Of Science And Technology, October 31, 2012)
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Abstract:
Voltammetric methods are applicable for the determination of a wide
variety of both organic and inorganic species. Its features are compact
equipment, simple sample preparation, short analysis time, high accuracy and
sensitivity. Voltammetry is especially suitable for laboratories in which only a
few parameters have to be monitored with a moderate sample throughput. Of
various electrode materials, glassy carbon electrode is particularly useful
because of its high electrical conductivity, impermeability to gases, high
chemical resistance, reasonable mechanical and dimensional stability and
widest potential range of all carbonaceous electrodes. Electrode modification
is a vigorous research area by which the electrochemical determination of
various analyte species is facilitated. The scope of pharmaceutical analysis
includes the analytical investigation of pure drug, drug formulations,
impurities and degradation products of drugs, biological samples containing
the drugs and their metabolites with the aim of obtaining data that can
contribute to the maximal efficacy and maximal safety of drug therapy.
This thesis presents the modification of glassy carbon electrode using
metalloporphyrin and dyes and subsequently using these modified electrodes
for the determination of various pharmaceuticals. The thesis consists of 9
chapters.
Description:
Department of Applied Chemistry
Cochin University of Science and Technology
Suresh, P V; Dr.Chandrasekaran,M(Cochin University of Science and Technology, October 10, 1996)
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Abstract:
In this thesis an attempt is made to explore the potential of marine fungi for the production of chitinolytic enzymes and to recognize the ability to hydrolyse native chitin through submerged as well as solid substrate fermentation culture conditions, using wheat bran and shellfish processing waste such as ‘prawn waste’ as solid substrates. Attempt was made to isolate a potential chitinase producing fungus from marine environment and to develop an ideal bioprocess for the
production ofchitolytic enzymes.Present study indicate scope for utilization of B. bassiana
for industrial production of chitinase using prawn waste as solid substrate employing solid substrate fermentation.
Description:
Department of Biotechnology. Cochin University of Science and Technology
Chinthu, Romeo; Dr. Paulose, C S(Cochin University of Science and Technology, August 17, 2012)
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Abstract:
The present study deals with the Cholinergic Receptor subtypes functional regulation in spinal cord injured monoplegic rats: Effect of 5-HT GABA and bone marrow cells.Spinal cord injury causes permanent and irrevocable motor deficits and neurodegeneration. Disruption of the spinal cord leads to diminished transmission of descending control from the brain to motor neurons and ascending sensory information. Behavioural studies showed deficits in motor control and coordination in SCI rats. Cholinergic system plays an important role in SCI, the evaluation of which provides valuable insight on the underlying mechanisms of motor deficit that occur during SCI. The cholinergic transmission was studied by assessing the muscarinic and nicotinic receptors; cholinergic enzymes- ChAT and AChE; second messenger enzyme PLC; transcription factor CREB and second messengers - IP3, cAMP and cGMP. We observed a decrease in the cholinergic transmission in the brain and spinal cord of SCI rats. The disrupted cholinergic system is the indicative of motor deficit and neuronal degeneration in the spinal cord and brain regions. SCI mediated oxidative stress and apoptosis leads to neuronal degeneration in SCI rats. The decreased expression of anti oxidant enzymes – SOD, GPx and neuronal cell survival factors - BDNF, GDNF, IGF-1, Akt and cyclin D2 along with increased expression of apoptotic factors – Bax, caspase-8, TNFa and NF-kB augmented the neuronal degeneration in SCI condition. BMC administration in combination with 5-HT and GABA in SCI rats showed a reversal in the impaired cholinergic neurotransmission and reduced the oxidative stress and apoptosis. It also enhanced the expression of cell survival factors in the spinal cord region. In SCI rats treated with 5-HT and GABA, the transplanted BMC expressed NeuN confirming that 5-HT and GABA induced the
differentiation and proliferation of BMC to neurons in the spinal cord. Neurotrophic factors and anti-apoptotic elements in SCI rats treated with 5-HT and GABA along with BMC rendered neuroprotective effects accompanied by improvement in behavioural deficits. This resulted in a significant reversal of altered cholinergic neurotransmission in SCI. The restorative and neuro protective effects of BMC in combination with 5-HT and GABA are of immense therapeutic
significance in the clinical management of SCI.
Description:
Department of Biotechnology, Cochin University of Science and Technology
Bindhu, Jacob; Dr.Sugunan, S(Cochin University of Science & Technology, February , 1998)
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Abstract:
In this thesis an attempt has been made to compare the catalytic activity of
some medium and large pore zeolites in a few alkylation and acylation reactions. The
work reported in the present study is basically centered around the following zeolites
namely, ZSM-5, mordenite, zeolite Y and beta. The major reactions carried out were
benzoylation of o-xylene, propionylation of toluene and anisole and benzylation of 0xylene.The programme involves the synthesis, modifications and characterization of
the zeolite catalysts by various methods. The influence of various parameters such as
non-framework cations, Si/AI ratio of zeolites, temperature of the reaction, catalyst
concentration, molar ratio of the reactants and recycling of the catalysts were also
examined upon the conversion of reactants and the formation of the desired products
in the alkylation / acylation reactions.The general conclusions drawn by us from the results obtained are summarized
in the last chapter of the thesis. Zeolite beta offers interesting opportunities as a
potential catalyst in alkylation reactions and the area of catalysis by medium and large
pore zeolites is very fascinating and there is plenty of scope for further research in this
field. Moreover, zeolite based catalysts are effective in meeting current industrial
processing and more stringent environment pollution limits.
Description:
Department of Applied Chemistry, Cochin
University of Science and Technology
Bindhu, Jacob; Dr.Sugunan, S(Cochin University Of Science And Technology, February 13, 1998)
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Abstract:
Zeolites have established themselves as industrial catalysts for over two
decades for a variety of hydrocarbon processing reactions where acidity and shape
selectivity are important factors. As solid catalysts, zeolites may be advantageous and
superior compared to their homogenous counterparts due to their characteristic
properties. It is only in recent years that the utility of zeolites for organic synthesis is
recognized for producing specific organic intermediates and fine chemicals in high
selectivity.
In this thesis an attempt has been made to compare the catalytic activity of
some medium and large pore zeolites in a few alkylation and acylation reactions. The
work reported in the present study is basically centered around the following zeolites
namely, ZSM-5, mordenite, zeolite Y and beta. The major reactions carried out were
benzoylation of o-xylene, propionylation of toluene and anisole and benzylation of oxylene.
.
The programme involves the synthesis, modifications and characterization of
the zeolite catalysts by various methods. The influence of various parameters such as
non-framework cations, Si/Al ratio of zeolites, temperature of the reaction, catalyst
concentration, molar ratio of the reactants and recycling of the catalysts were also
examined upon the conversion of reactants and the formation of the desired products
in the alkylation/ acylation reactions.
The general conclusions drawn by us from the results obtained are summarized
in the last chapter of the thesis. Zeolite beta ofi'ers interesting opportunities as a
potential catalyst in alkylation reactions and the area of catalysis by medium and large
pore zeolites is very fascinating and there is plenty of scope for further research in this
field. Moreover, zeolite based catalysts are effective in meeting current industrial
processing and more stringent environment pollution limits.
Description:
Department of Applied Chemistry, Cochin
University of Science and Technology
Johny,Scaria; Unnikrishnan Nair, N(Department of Statistics,Faculty of Science, 2003)
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Abstract:
The study deals with the distribution theory and applications of concomitants from the Morgenstern family of bivariate distributions.The Morgenstern system of distributions include all cumulative distributions of the form FX,Y(X,Y)=FX(X) FY(Y)[1+α(1-FX(X))(1-FY(Y))], -1≤α≤1.The system provides a very general expression of a bivariate distributions from which members can be derived by substituting expressions of any desired set of marginal distributions.It is a brief description of the basic distribution theory and a quick review of the existing literature.The Morgenstern family considered in the present study provides a very general expression of a bivariate distribution from which several members can be derived by substituting expressions of any desired set of marginal distributions.Order statistics play a very important role in statistical theory and practice and accordingly a remarkably large body of literature has been devoted to its study.It helps to develop special methods of statistical inference,which are valid with respect to a broad class of distributions.The present study deals with the general distribution theory of Mk, [r: m] and Mk, [r: m] from the Morgenstern family of distributions and discuss some applications in inference, estimation of the parameter of the marginal variable Y in the Morgestern type uniform distributions.
Zachariah,E J; Dr.Nair, K G(Cochin University of Science And Technology, August , 1981)
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Abstract:
The need for improved feed systems for large reflector antennas employed in Radio Astronomy and Satellite tracking spurred the interest in horn antenna research in
the 1960's. The major requirements were to reduce spill over, cross-polarisation losses,and to enhance the aperture efficiency to the order of about 75-8O%L The search for such a feed culminated in the corrugated horn. The corrugat1e 1 horn triggered widespread interest and enthusiasm, and a large amount of work(32’34’49’5O’52’53’58’65’75’79)has already been done on this type of antennas. The properties of corrugated surfaces has been investigated in detail.
It was strongly felt that the flange technique and the use of corrugated surfaces could be merged together to obtain the advantages of both. This is the idea behind the present work. Corrugations are made on the surface of flange elements. The effect of various corrugation parameters are studied. By varying the flange parameters, a good amount of data is collected and analysed to ascertain the effects of corrugated flanges. The measurements are repeated at various frequencies, in the X— and S-bands. The following parameters of the system were studied: (a) beam shaping (b) gain (c) variation of V.S.U.R. (d) possibility of obtaining circularly polarised
radiation from the flanged horn. A theoretical explanation to the effects of corrugated flanges
is attempted on the basis of the line-source theory. Even though this theory utilises a simplified model for the calculation of radiation patterns, fairly good agreement between the computed pattern and experimental results are observed.
Description:
Department of physics, Cochin University of Science And Technology
Aiswarya, N.; Dr. M.R. Prathapachandra Kurup(Cochin University of Science and Technology, April 10, 2016)
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Abstract:
The current scenario of coordination chemistry is witnessing the exploitation
of coordination bonds and noncovalent interactions to generate self-assemblies of
various dimensions having not only aesthetic values but also countless applications
and that paved way for supramolecular chemistry/crystal engineering. Most of
such fascinating work employs Schiff bases obtained by the condenzation of an
amine and a carbonyl compound. The use of diamines in the synthesis of highnuclearity
complexes utilizes the bridging capacity of phenoxo atoms. Whereas in
the case of N2O donor tridentate Schiff bases (N-substituted diamines with
salicylaldehyde or its derivatives), coligands are employed to generate structures of
variable composition apart from satisfying the coordination number. Among the
various coligands known, pseudohalides (azido, cyanato, thiocyanato, dicyanamido)
deserve special attention on account of its versatile modes of binding. In addition
to the structural variety, such Schiff base complexes have its signature in the field
of catalysis, luminescence, gas adsorption and magnetic materials which make the
arena conspicuous. The recognition of plasticity of copper(II) metal with respect to
its coordination number and its ubiquitous nature as active sites in many metalloenzymes
fuelled us to work with this metal. The results of our efforts to explore
the role of various interaction forces constitute the subject matter of the thesis
entitled “Crystalline architectures of copper(II) complexes derived from halogen
substituted carbonyl compounds: Interplay of covalent and non-covalent forces”.
The work embodied in this thesis was carried out by the author in the Department of
Applied Chemistry, CUSAT, Kochi, during the period 2011-2016 and is divided into
eight chapters.
Jinsa, Jacob Mary; Dr.Prathapachandra Kurup,M R(Cochin University Of Science And Technology, September , 2013)
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Abstract:
Thiosemicarbazones have emerged as an important class of ligands
over a period of time, for a variety of reasons, such as variable donor
properties, structural diversity and biological applications. Interesting as
the coordination chemistry may be, the driving force for the study of these
ligands has undoubtedly been their biological properties and the majority
of the 3000 or so publications on thiosemicarbazones since 2000 have
alluded to this feature. Thiosemicarbazones with potential donor atoms in
their structural skeleton fascinate coordination chemists with their versatile
chelating behavior. The thiosemicarbazones of aromatic aldehydes and
ketones form stable chelates with transition metal cations by utilizing both
their sulfur and azomethine nitrogen as donor atoms. They have been
shown to possess a diverse range of biological activities including
anticancer, antitumor, antibacterial, antiviral, antimalarial and antifungal
properties owing to their ability to diffuse through the semipermeable
membrane of the cell lines. The enhanced effect may be attributed to the
increased lipophilicity of the metal complexes compared to the ligand
alone.
Description:
Department of Applied Chemistry, Cochin University of Science and Technology
Jessy Emmanuel; Dr.Prathapachandra Kurup,M R(Cochin University Of Science And Technology, July 26, 2012)
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Abstract:
Supra molecular architectures of coordination complexes of liydrazones
through non covalent interactions have been explored. Molecular self—assernbly
driven by weak interactions such as hydrogen— bonding, K '”T[, C-1-I‘ "TE, van
der Waals interactions, and so forth are currently of tremendous research
interest in the fields of molecule based materials. The directional properties of
the hydrogembonding interaction associate discrete molecules into aggregate
structures that are sufficiently stable to be considered as independent chemical
species. Chemistry can borrow nature’s strategy to utilize hydrogen-bonding as
Well as other noncovalent interactions as found in secondary and tertiary
structures of proteins such as the double helix folding of DNA, hydrophobic
selflorganization of phospholipids in cell membrane etc. In supramolecular
chemistry hydrogen bonding plays an important role in forming a variety of
architectures. Thus, the wise modulation and tuning of the complementary sites
responsible for hydrogen—bond formation have led to its application in
supramolecular electronics, host-guest chemistry, self-assembly of molecular
capsules, nanotubes etc. The work presented in this thesis describes the synthesis and
characterization of metal complexes derived from some substituted
aroylhydrazones. The thesis is divided into seven chapters.
Description:
Department of Applied Chemistry, Cochin University of Science and
Technology
Priya Rajan, S; Dr.Mohanan, P V(Cochin University Of Science And Technology, May , 2013)
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Abstract:
The scope of the work was to synthesis few biologically active derivatives
of curcumin. The derivatives were prepared by altering the keto-enol centre of
curcumin by various reagents. This particular reaction centre for preparing
derivative was selected keeping in mind the controversy regarding the major site
responsible for antioxidant mechanism of curcumin. Most of the mechanistic study
done earlier was by varying the constituents in one or both of the phenol ring
present in the curcumin. The alterations at the keto-enol moiety may throw an
insight into the role of the diketo moiety towards the antioxidant mechanism. Since
recently curcumin has been suggested as a chemotherapeutic agent for various
ailments, we also decided to check the DNA intercalating property of the
derivatives synthesised.
Description:
Department of Applied Chemistry
Cochin University of Science and Technology