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Abstract:
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Voltammetric methods are applicable for the determination of a wide
variety of both organic and inorganic species. Its features are compact
equipment, simple sample preparation, short analysis time, high accuracy and
sensitivity. Voltammetry is especially suitable for laboratories in which only a
few parameters have to be monitored with a moderate sample throughput. Of
various electrode materials, glassy carbon electrode is particularly useful
because of its high electrical conductivity, impermeability to gases, high
chemical resistance, reasonable mechanical and dimensional stability and
widest potential range of all carbonaceous electrodes. Electrode modification
is a vigorous research area by which the electrochemical determination of
various analyte species is facilitated. The scope of pharmaceutical analysis
includes the analytical investigation of pure drug, drug formulations,
impurities and degradation products of drugs, biological samples containing
the drugs and their metabolites with the aim of obtaining data that can
contribute to the maximal efficacy and maximal safety of drug therapy.
This thesis presents the modification of glassy carbon electrode using
metalloporphyrin and dyes and subsequently using these modified electrodes
for the determination of various pharmaceuticals. The thesis consists of 9
chapters. |