DNA Interaction and Catalytic Activity Studies of Some New Transition Metal Complexes of Schiff Bases Derived from Quinoxaline

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DNA Interaction and Catalytic Activity Studies of Some New Transition Metal Complexes of Schiff Bases Derived from Quinoxaline

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dc.contributor.author Leeju, P
dc.contributor.author Dr.Mohammed Yusuff, K K
dc.date.accessioned 2011-10-15T05:16:13Z
dc.date.available 2011-10-15T05:16:13Z
dc.date.issued 2011-04
dc.identifier.uri http://dyuthi.cusat.ac.in/purl/2354
dc.description Dept.of Applied Chemistry,Cochin University of Science and Technology en_US
dc.description.abstract In this thesis we report the synthsis and characterisation of new transition metal complexes of Pd(II),Cu(II),Ru(II) and Ir(III) of Schiff bases derived from quinoxaline-2-carboxaldehyde/3-hydroxyquinoxaline-2-carboxaldehyde and 5-aminoindazole.6-aminoindazole or 8-aminoquinoline.The complexes have been characterised by spectral and analytical data.Pd(II) and Cu(II) form square planar complexes and Ru(III) and Ir(III) form ctahedral complexes with these Schiff bases.The DNA binding properties of theses synthesised complexes have been studied by various methods including electronic absoption spectroscopy,cyclic voltammetry,different pulse voltammetry and circular dichroism spectra were used.Gel electrophoresis experiments were also performed to investigate the DNA cleavage of theses complexes.Furthermore Ru(III) and Ir(III) complexes find application as oxidation and hydogenation catalsts. The studies on catalytic activities has been presented.The metal complexes presented in this thesis assure significance as they contribute to the development of new DNA binding agents and antibacterial and anticancer drugs. en_US
dc.language.iso en en_US
dc.publisher Cochin University of Science & Technology en_US
dc.subject Catalytic activity en_US
dc.subject Transition metal complex en_US
dc.subject Schiff bases en_US
dc.subject Quinoxaline en_US
dc.title DNA Interaction and Catalytic Activity Studies of Some New Transition Metal Complexes of Schiff Bases Derived from Quinoxaline en_US
dc.type Thesis en_US
dc.contributor.faculty Science en_US


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