Ponnachan,P T C; Paulose,C S; Panikkar,K R(Department of Biotechnolgy, 1993)
[+]
[-]
Abstract:
Alloxan induced diabetic animal model was
used to evaluate the antidiabetic effect of alkaloids
extracted from the leaves of Aegis marine/ose. The
alkaloid extract maintained the weight of animals
near to that of control ones - whereas there was a
decrease in the body weight of diabetic animals. A
significant increase in blood glucose (342. 14 -+-
14.89 mg/dl) was seen in diabetic animals but in
alkaloid treated group the blood glucose was lowered
(90: 12 +_5.81 mg/dl). There was no decrease in
blood urea arid sreum cholesterol in the alkaloid
treated group of diabetic animals. The liver
glycogen decreased in diabetic animals (1.27+.12
g/100g of wet tissue) and the treatment brought the
glycogen level to that of control ones (2.51 +.75
g/100 g of wet tissue). The result show that the
alkaloid extract has hypoglycaemic activity.