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Abstract:
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Acid and alkaline DNase activities in partially purified preparations from young and old chick brain were measured. The
specific activity of acid DNase from old brain was lower by about 50% than that of enzyme from young brain , whereas alkaline
DNase exhibited only marginal difference in activity of the two preparations . Study of various properties, viz. heat-stability
and effect of exogenous compounds like Mg=', Hgl', Zn=', PHM B , on these enzymes revealed that while acid DNase in old
brain is more susceptible to heat and heavy metal ion inhibition , alkaline DNase is devoid of any age-dependent variation in
its properties. |