Novel Strategies for Heterocyclic Constructions via 1, 4-Dipolar Intermediates

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Novel Strategies for Heterocyclic Constructions via 1, 4-Dipolar Intermediates

Show simple item record Sreekanth,A R Vijay Nair,G 2008-10-10T08:50:00Z 2008-10-10T08:50:00Z 2002-11
dc.description.abstract In the thesis entitled " Novel Strategies for Heterocyclic Constructions via 1 ,4-Dipolar Intermediates"Synthesis of a complex organic molecules essentially involves the formation of carbon-carbon and carbon-heteroatom bonds. Various synthetic methods are available for these processes involving ionic, pericyclic and radical reactions. Among the pericyclic reactions, dipolar cycloaddition reactions, introduced by Huisgen, have emerged as a very powerful tool for heterocyclic construction. Heterocyclic compounds remain an important class of organic molecules due to their natural abundance and remarkable biological activity, thus constituting an intergral part of pharmaceutical industry. In this respect, developing newer synthetic methodology for heterocyclic construction has been an area of immense interest. In recent years, 1,3-dipolar cycloaddition reactions proved to be efficient routes to a wide variety of five membered heterocycles, as attested by their application in the total synthesis of various complex organic molecules. However, the potential application of similar 1,4- dipolar cycloaddition reactions for the construction of six memebered heterocycles remained underexploited. In this context, a systematic investigation of the reactivity of 1,4-dipoles generated from nitrogen heterocycles (pyridine and its analogues) and dimethyl acetylenedicarboxy!ate (DMAD) towards various dipolarophiles has been carried out and the results are embodied. en_US
dc.language.iso en en_US
dc.subject 1, 4-Dipolar Intermediates en_US
dc.subject carbon-heteroatom bond en_US
dc.subject Dipolar cycloaddition reactions en_US
dc.subject Dimethyl acetylenedicarboxy!ate (DMAD) en_US
dc.subject Dipolarophiles en_US
dc.title Novel Strategies for Heterocyclic Constructions via 1, 4-Dipolar Intermediates en_US
dc.type Thesis en_US

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