Testicular Function in Biotin-Deficient Adult Rats

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Testicular Function in Biotin-Deficient Adult Rats

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dc.contributor.author Paulose,C S
dc.contributor.author Thliveris,J A
dc.contributor.author Dakshinamurti,K
dc.contributor.author Viswanathan,M
dc.date.accessioned 2008-08-13T09:40:07Z
dc.date.available 2008-08-13T09:40:07Z
dc.date.issued 1989
dc.identifier.uri http://dyuthi.cusat.ac.in/purl/650
dc.description.abstract We have studied testicular function in the biotin- deficient rat biochemically and morphologically. Serum testosterone and luteinizing hormone (LH) levels were decreased significantly in the deficient rats. Administration of biotin or gonadotropins to the deficient rats reversed this decrease in serum testosterone. There was no difference in the serum cholesterol level between the control and biotin-deficient rats. A significant degree of sloughing of seminiferous tubule germinal epithelium was noticed in the biotin-deficient rat testes. Biotin treatment of biotindeficient rats reversed this condition whereas testosterone treatment was without any effect. The development and maintenance of morphological and functional integrity of the seminiferous tubules appears to require a biotin-mediated step in addition to testosterone. en_US
dc.language.iso en en_US
dc.publisher Department of Biotechnology en_US
dc.subject Testicular Function en_US
dc.subject Testosterone en_US
dc.subject Biotin Deficiency en_US
dc.subject Testis en_US
dc.title Testicular Function in Biotin-Deficient Adult Rats en_US
dc.type Working Paper en_US


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