Pineal indoleamine metabolism in pyridoxine-deficient rats

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Pineal indoleamine metabolism in pyridoxine-deficient rats

Show simple item record Viswanathan,M Siow,Y L Paulose,C S Dakshinamurti,K 2008-08-04T12:44:36Z 2008-08-04T12:44:36Z 1988-05-24
dc.description.abstract Pvridoxine deficiency causes physiologically significant decrease in brain serotonin (5-HT) due to decreased decarboxylation of 5- hvdroxvtrvptophan (5-HTP). We have examined the effect of pyridoxine deficiency on indoleamine metabolism in the pineal gland, a tissue with high indoleamine turnover. Adult male Sprague-Dawley rats were fed either a pyridoxine-supplemented or pyridoxinedeficient diet for 8 weeks. Pyridoxine deficiency did not alter the pattern of circadian rhythm of pineal 5-HT. 5-hvdroxvindoleacetic acid (5-HIAA), V-acetvlserotonin (NAS). and melatonin. However the levels of these compounds were significantly lower in the pineal glands of pyridoxine-deficient animals. Pineal 5-HTP levels were consistently higher in the pyridoxine-deficient animals and a conspicuous increase was noticed at 22.00 h. Increase in pineal NAS and melatonin levels caused by isoproterenol (5 mg kg at 17.00 h) were significantly lower (P < 0.05) in the pyridoxine-deficient animals. Treatment of pyridoxine-deficient rats with pvridoxine restored the levels of pineal 5-HT, 5-HIAA. NAS. and melatonin to values seen in pyridoxine-supplemented control animals. These results suggest that 5-HT availability could be an important factor in the regulation of the synthesis of pineal NAS and melatonin. en_US
dc.language.iso en en_US
dc.publisher Department of Biotechnology en_US
dc.subject Pineal gland en_US
dc.subject Pyridoxine deficiency en_US
dc.subject Aromatic amino acid decarboxylase en_US
dc.subject Serotonin en_US
dc.subject Melatonin en_US
dc.title Pineal indoleamine metabolism in pyridoxine-deficient rats en_US
dc.type Working Paper en_US

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