Viswanathan,M; Paulose,C S; Lal,K J; Sharma,S K; Dakshinamurti,K(Department of Biotechnology, November 27, 1989)
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Abstract:
Moderate pyridoxine deficiency in adult male Sprague-Dawley rats results in significant hypertension,
associated with a general sympathetic stimulation , including an increase in the turnover of norepinephrine
in the heart. Treatment of these rats with pyridoxine reversed blood pressure to normal within 24 h. Treatment
of pyridoxine-deficient rats with clonidine or x-methyl dihydroxyphenylalanine (x-methyl DOPA)
also reduced the blood pressure of these animals to normal . There was also a significant increase in the
Bma, of high and low affinity [3H]p-amino-clonidine binding to crude synaptosomal membrane preparations
of the brain stem of deficient rats indicating chronic underexposure of)(, adrenoreceptors to endogenous
norepinephrin.