Mohanan,Valiyaveettil; Balarama Kaimal,S; Paulose, Cheramadathikudyil S(Department of Bio Technology, August 30, 2004)
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Abstract:
The present study was to investigate the rote of central 5-11T and 5-HT,:v receptor Lindin4o
and acne expression in it 'at mo(lel of pancreatic regeneration using 60" -, pancreatcutumy.
The pancreatic regeneration was evaluated by 5-HT content and 5-HT,,receptor gene
expression in the cerebral cortex (CC) and brain stem MS) of Alain opcrate,t, 7 It utd
7 (.lays panereatectomised rats. 5-11T content significantly increased in the CC' (I' 1.1)11
and 13S (P 0.05) of 72 Ii p.ntcreateetomiscd rats. Sympathetic activity was decreased as
indicated by the significantly decreased norcpiuephrine (NIi) and epinephrine (FTI) Icvcl
(1' < 0.001 and P < 0.05) in the plasma of 72 h panereateetomised rats. 5-111 ,^, receptor
density and affinity was decreased in the CC (P < 0.01) and BS (P < 0.01). These rh:)nge;
correlated with a diminished 5-IITIA receptor mRNA expression in the brain region. studied.
Our resuils suggest that the brain 5-11T through 5-HTin receptor has it funcuon:0 rule
iii 11w pi+ncreatic regcner:ttion through the sympathetic regulation.