Eswar Shankar,P N; Santhosh,K T; Paulose,C S(Department of Biotechnology, March , 2006)
[+]
[-]
Abstract:
The stimulatory effect of dopamine through dopamine 1)2
receptor on glucose - induced insulin secretion was studied in the
pancreatic islets in nitro. I)oparnilie signifieanlly stimula(ed insulin
secretion at a concentration of 10 a N1 in the presence of
high,glucose ( 20 nii1 ). ' fhe higher concentrations of dopamine
(111 -1() 4) inhibited glucose- induced insulin secretion in the
presence of both 4 mM1 and 20 m M glucose. Stimulatory and
inhibitory effect of dopamine on glucose - induced insulin secretion
was reverted by the addition of dopamine 1)2 receptor antagonists
such as butaclamol and sulpiride . Norepinephrine (NE) at 111 4 11
concentration inhibited the dopamine uptake as well as its
stimulatory effect at 11) - 8 IN1 concentration on glucose induced
insulin secretion. Our results suggest that dopamine exerts a
differential effect on glucose -induced insulin secretion through
dopamine D2 receptor and it is essential for the regulation of
glucose-induced insulin secretion by pancreatic islets.