Paulose,C S; Kanungo, M S(Department of Biotecnology, April 21, 1982)
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Abstract:
The binding of (-)[ 3H ]dihydroalprenolol , an antagonist of norepinephrine , to $-adrenergic receptors
in different regions of the brain of male and female rats of various ages was measured . The binding to the
synaptosomal fraction of corpus striatum , hypothalamus, cerebral cortex, cerebellum and the brainstems
shows a significant decrease in the binding in old rats of both sexes . Only in the female corpus striatal
region, the binding in the adult and the old is the same . In the case of females, the highest binding is seen
in the young. In the male, an increase in binding occurs up to adulthood , after which it declines,
suggesting a definite sex-related difference in the Q-adrenergic receptor.
Eswar Shankar,P N; Santhosh,K T; Paulose,C S(Department of Biotechnology, March , 2006)
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Abstract:
The stimulatory effect of dopamine through dopamine 1)2
receptor on glucose - induced insulin secretion was studied in the
pancreatic islets in nitro. I)oparnilie signifieanlly stimula(ed insulin
secretion at a concentration of 10 a N1 in the presence of
high,glucose ( 20 nii1 ). ' fhe higher concentrations of dopamine
(111 -1() 4) inhibited glucose- induced insulin secretion in the
presence of both 4 mM1 and 20 m M glucose. Stimulatory and
inhibitory effect of dopamine on glucose - induced insulin secretion
was reverted by the addition of dopamine 1)2 receptor antagonists
such as butaclamol and sulpiride . Norepinephrine (NE) at 111 4 11
concentration inhibited the dopamine uptake as well as its
stimulatory effect at 11) - 8 IN1 concentration on glucose induced
insulin secretion. Our results suggest that dopamine exerts a
differential effect on glucose -induced insulin secretion through
dopamine D2 receptor and it is essential for the regulation of
glucose-induced insulin secretion by pancreatic islets.
Paulose,C S; Dakshinamurti,K; Subah,Packer; Newman,L Stephens(Department of Biotechnology, December 8, 1987)
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Abstract:
Pyridoxal phosphate is the coenzyme of various decarboxylases involved in the formation
of monoamine neurotransmitters such as y-aminobutyric acid , serotonin , dopamine, and norepinephrine
. Adult male Sprague-Dawley rats placed on a pyridoxine -deficient diet for 8 weeks showed
significant hypertension compared with pyridoxine -supplemented controls . Hypothalamic contents of
pyridoxal phosphate , y-aminobutyric acid, and serotonin in the pyridoxine - deficient rats were significantly
lower than those in pyridoxine -supplemented controls . Hypertension was associated with
sympathetic stimulation . Treatment of pyridoxine-deficient rats with a single dose of pyridoxine (10
mg/kg body weight) reversed the blood pressure to normal levels within 24 hours, with concomitant
restorations of hypothalamic serotonin and y-aminobutyric acid as well as the return of plasma
norepinephrine and epinephrine to normal levels . Also, pyridoxine treatment reversed the hypothalamic
hypothyroidism observed in pyridoxine -deficient rats . These results indicate an association
between pyridoxine deficiency and sympathetic stimulation leading to hypertension.