Paulose,C S; Dakshinamurti,K(Department of Biotechnology, April 24, 1984)
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Abstract:
The high-affinity of [3H]y-aminobutyric acid (GABA) to GABAA receptors and [3H]baclofen to
GABAB receptors were studied in the cerebellum of pyridoxine-deficient rats and compared to
pyridoxine-supplemented controls. There was a significant increase in the maximal binding ( Bmax) of both
GABAA and GABAB receptors with no significant difference in their binding affinities (Kd). The changes
observed suggest a supersensitivity of GABAA and GABAB receptors which seems to correlate negatively
with the concentration of GABA in the cerebellum of pyridoxine-deficient rats.