Girish Kumar,K; Chowdary, K P R; Devala Rao, G(Indian Journal Of Pharmaceutical Sciences, January 8, 1999)
[+]
[-]
Abstract:
Two simple and sensitive spectrophotometric methods (A and B)in the visible region have been developed for the determination of nimesulide in bulk and in dosage forms.Method A is based on the reaction of reduced nimesulide with nitrous acid followed by its coupling with phloroglucinol to yield an yellow colored azo dye with an absorption maximum of 400 nm and method B is based on the reaction of reduced nimesulide with p-dimethylamino benzaldehyde(PDAB) to form an yellow colored chromogen wiht an absorption maximum of 415 nm.When pharmaceutical preparations (Tablets and suspension) were analysed, the results obtained by the proposed methods are in good agreement with the labelled amounts and are comparable with the results obtained by a reported method.recovery in both the method is 98-101 %.
Kumar,K G; Augustine,P; John,S(Department of Applied Chemistry, June 21, 2007)
[+]
[-]
Abstract:
A novel electrochemical sensor has been developed for the determination of nimesulide.
The sensor is based on the NIM- molybdophosphoric acid (MPA) as the electroactive
material in PVC matrix in presence of bis(2-ethyl hexyl) phthalate (BEP) as a
plasticizer. The sensor showed a fast, stable, near Nernstian response for 1 × 10-2 –1 ×
10-6 M NIM over the pH range 5 – 8 with a slope 55.6 ±0.5m V/decade and the response
time is < 45 s. Selectivity coefficient data for some common ions show negligible
interferences. The sensor was successfully applied for the determination of NIM in
tablet and the results obtained are in good agreement with those obtained by the official
method.