Dopamine D2 and 5-HT2A receptor gene expression

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Dopamine D2 and 5-HT2A receptor gene expression

Show simple item record Akash,George K Dr. Paulose, C S 2013-10-26T06:42:04Z 2013-10-26T06:42:04Z 2006-09-15
dc.description Department of Biotechnology, Cochin University of Science and Technology en_US
dc.description.abstract Neuronal dopamine and serotonin receptors are widely distributed in the central and the peripheral nervous systems at different levels. Dopaminergic and serotonergic systems have crucial role in aldehyde dehydrogenase regulation Stimulation of autonomic nervous system during ethanol treatment is suggested to be an important factor in regulating the ALDH function. The ALDH enzyme activity was increased in plasma, cerebral cortex, and liver but decreased in cerebellum. The ALDH enzyme affinity was decreased in plasma, brainstem and liver and increased in cerebral cortex and cerebellum. Dopamine and serotonin content decreased in liver and brain regions - cerebral cortex, corpus striatum of ethanol treated rats with an increased HVA/DA, 5-HIAA/5-HT tumover rate. Dopamine content decreased in brainstem with an increased HVA/DA turnover rate and serotonin content decreased with an increased 5-HIAA/5-HT turnover rate in the brainstem of ethanol treated rats compared to control. Serotonin content increased in hypothalamus with a decreased 5-HIAA/5—HT turnover rate where as dopamine content decreased in hypothalamus with an increased HVA/DA tumover rate of ethanol treated rats compared to control.alterations of DA D2 and 5-HTQA receptor function and gene expression in the cerebellum, hypothalamus, corpus striatum, cerebral cortex play an important role in the sympathetic regulation of ALDH enzyme in ethanol addiction. There is a serotonergic and dopaminergic functional regulation of ALDH activity in the brain regions and liver of ethanol treated rats. Gene expression studies of DA D2 and 5'HT2A studies confirm these observations. Perfusion studies using DA, 5-HT and glucose showed ALDH regulatory function. Brain activity measeurement using EEG showed a prominentfrontal brain wave difference. This will have immense clinical significance in the management of ethanol addiction. en_US
dc.description.sponsorship Cochin University of Science and Technology en_US
dc.language.iso en en_US
dc.publisher Cochin University of Science and Technology en_US
dc.subject Central nervous system en_US
dc.subject Effect of ethanol on brain DA receptors en_US
dc.subject Body weight and ethanol consumption en_US
dc.subject Liver and ethanol en_US
dc.subject Epinerphrine and norepinephrine. en_US
dc.title Dopamine D2 and 5-HT2A receptor gene expression en_US
dc.title.alternative Their functional role on aldehyde dehydrogenase regulations in ethenol treated rats en_US
dc.type Thesis en_US

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