Reni, George; Dr.Sugunan, S(Cochin University of Science And Technology, May , 2013)
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Abstract:
Mesoporous silica nanoparticles provide a non-invasive and biocompatible
delivery platform for a broad range of applications in therapeutics, pharmaceuticals
and diagnosis. Additionally, mesoporous silica materials can be synthesized
together with other nanomaterials to create new nanocomposites, opening up a
wide variety of potential applications. The ready functionalization of silica
materials makes them ideal candidates for bioapplications and catalysis. These
properties of mesoporous silica like high surface areas, large pore volumes and
ordered pore networks allow them for higher loading of drugs or biomolecules.
Comparative studies have been made to evaluate the different procedures;
much of the research to date has involved quick exploration of new methods
and supports. Requirements for different enzymes may vary, and specific
conditions may be needed for a particular application of an immobilized
enzyme such as a highly rigid support.
In this endeavor, mesoporous silica materials having different pore size
were synthesized and easily modified with active functional groups and were
evaluated for the immobilization of enzymes. In this work, Aspergillus niger
glucoamylase, Bovine liver catalase, Candida rugosa lipase were immobilized
onto support by adsorption and covalent binding. The structural properties of
pure and immobilized supports are analyzed by various characterization
techniques and are used for different reactions of industrial applications.
Description:
Department of Applied Chemistry
Cochin University of Science and Technology