Jeevanand, E S; Dr.Unnikrishnan Nair, N(December 20, 1993)
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Abstract:
This thesis Entitled Bayesian inference in Exponential and pareto populations in the presence of outliers. The main theme of the present thesis is focussed on various estimation problems using the Bayesian appraoch, falling under the general category of accommodation procedures for analysing Pareto data containing outlier. In Chapter II. the problem of estimation of parameters in the classical Pareto distribution specified by the density function. In Chapter IV. we discuss the estimation of
(1.19) when the sample contain a known number of outliers under three different data generating mechanisms, viz. the exchangeable model. Chapter V the prediction of a future observation based on a random sample that contains one contaminant. Chapter VI is devoted to the study of estimation
problems concerning the exponential parameters under a k-outlier model.
Description:
Department of
Mathematics and Statistics, Cochin University of Science
and Technoloy
Mathew, K T; Dr.Gopalakrishnan Nair, K(Cochin University of Science And Technology, May , 1978)
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Abstract:
In the present thesis, possibility of beam shaping of sectoral horns and corner reflector systems'has been studied in detail. The experimental results obtained in the above two cases are compared. As far as the flanged sectoral horns are concerned, the special advantage is that the gain is increased without impairing impedance conditions. An intense study on corner reflector antennas shows that the been broadening or focussing will be possible by adjusting parameters
involved. Beam tilting by imposing asymmetries is another interesting property of the systems. A comprehensive study of these fields has been presented in Chapter II. Chapter III is exclusively for describing the experimental techniques used in the present investigation.
In Chapter IV, experimental results on flanged sectoral horns and corner reflector eyetses are presented. A comparative analysis of the experimental results obtained with flanged sectoral horns and corner reflector systems is presented in the Chapter V. The similarity and close resemblance in each aspects are shown by presenting typical results from these two eysteee.
Theoretical aspects of both types of antennas are considered in Chapter VI. Attempts are made for co-ordinating the theoretical aspects and drawing a final conclusion. In Chapter VII. the final conclusion that the flanged sectoral horn may be considered as a corner reflector system has been drawn. The importance of the conclusions and usefulness are pointed out. The scope for further
work in these lines has been indicated.
Description:
Department of physics, Cochin University of Science And Technology
Reshma ., P. L; Dr. Raghu, K.G(Cochin University of Science and Technology, May 5, 2016)
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Abstract:
Myocardial ischemia is caused by the inadequate supply of blood to the myocardium usually as a result of coronary artery disease. Cardiovascular disease is the leading cause of death worldwide and coronary artery disease is the greatest contributor, with 7.5 million deaths annually. Currently available drugs are able to alleviate the symptoms but have undesirable effects and secondary complications. Tribulus terrestris L. root and fruit are used in Ayurveda to treat heart ailments. But a scientific validation of the protective property of the herb against myocardial ischemia and the mechanism by which Tribulus terrestris L. mediates the protection has not been carried out. The objective of the present thesis is to elucidate the molecular mechanism of the beneficial property of Tribulus terrestris L. fruit and root against myocardial ischemia and cardiac dysfunctions by employing in vitro and in vivo models.
Lalitha Devi, Gottumukkala; Rajeev Kumar, Sukumaran(Cochin University Of Science And Technology, July , 2014)
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Abstract:
In the current study, a novel non-acetone forming butanol and ethanol producer
Was isolated and identified. Based on the 16s rDNA sequence BLAST and phylogenetic analyses, it was found to have high similarity with the reported hydrogen producing strains of Clostridium sporogenes. Biochemical studies revealed that it is lipase and protease positive. The lipolytic and proteolytic properties are the very important characteristics of Clostridium sporogenes. Sugar utilization profile studies were positive for glucose, saccharose, cellobiose and weakly positive result to xylose. This study demonstrated C. sporogenes BE01, an isolate from NIIST is having potential to compete with existing, well known butanol producers with the advantage of no acetone in the final solvent mixture. Rice straw hydrolysate is a potent source of substrate for butanol production by C. sporogenes BE01. Additional supplementation of vitamins and minerals were avoided by using rice straw hydrolysate as substrate. Its less growth, due to the inhibitors present in the hydrolysate and also inhibition by products resulted in less efficient conversion of sugars to butanol. Calcium carbonate played an important role in improving the butanol production, by providing the buffering action during fermentation and stimulating the electron transport mediators and redox reactions favoring butanol production. Its capability to produce acetic acid, butyric acid and hydrogen in significant quantities during butanol production adds value to the conversion process of lignocellulosic biomass to butanol. High cell density fermentation by immobilizing the cells on to ceramic particles improved the solvents and VFA production. Reduced sugar utilization from the concentrated hydrolysate could be due to accumulation of inhibitors in the hydrolysate during concentration. Two-stage fermentation was very efficient with immobilized cells
and high conversions of sugars to solvents and VFAs were achieved. The information obtained from the study would be useful to develop a feasible technology for conversion of lignocellulosic biomass to biobutanol.
Naseema,A; Selvam,G S(Department of Biotechnology, January , 2000)
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Abstract:
The current study is an attempt to find a means of lowering oxalate concentration in individuals susceptible to recurrent calcium oxalate stone disease.The formation of renal stone composed of calcium oxalate is a complex process that remains poorly understood and treatment of idiopathic recurrent stone formers is quite difficult and this area has attracted lots of research workers. The main objective of this work are to study the effect of certain mono and dicarboxylic acids on calcium oxalate crystal growth in vitro, isolation and characterization of oxalate degrading bacteria, study the biochemical effect of sodium glycollate and dicarboxylic acids on oxalate metabolism in experimental stone forming rats and To investigate the effect of dicarboxylic acids on oxalate metabolism in experimental hyperoxaluric rats. Oxalic acid is one of the most highly oxidized organic compound widely distributed in the diets of man and animals, and ingestion of plants that contain high concentration of oxalate may lead to intoxication. Excessive ingestion of dietary oxalate may lead to hyperoxaluria and calcium oxalate stone disease.The formation of calcium oxalate stone in the urine is dependent on the saturation level of both calcium and oxalate. Thus the management of one or both of these ions in individuals susceptible to urolithiasis appears to be important. The control of endogenous oxalate synthesis from its precursors in hyperoxaluric situation is likely to yield beneficial results and can be a useful approach in the medical management of urinary stones. A variety of compounds have been investigated to curtain endogenous oxalate synthesis which is a crucial factor, most of these compounds have not proved to be effective in the in vivo situation and some of them are not free from the toxic effect. The non-operative management of stone disease has been practiced in ancient India in the three famous indigenous systems of medicine, Ayurveda, Unani and Siddha, and proved to be effective.However the efficiency of most of these substances is still questionable and demands further study. Man as well as other mammals cannot metabolize oxalic acid. Excessive ingestion of oxalic acid can arise from oxalate rich food and from its major metabolic precursors, glycollate, glyoxylate and ascorbic acid can lead to an acute oxalate toxicity. Increasedlevels of circulating oxalate, which can result in a variety of diseases including renal failure and oxalate lithiasis. The ability to enzymatically degrade oxalate to less noxious Isubstances, formate and CO2, could benefit a great number of individuals including those afflicted with hyperoxaluria and calcium oxalate stone disease.
Bismi, Nadh G; Dr. Ramachandran Nair, V K(Cochin University of Science and Technology, June , 2005)
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Abstract:
The present work is organized into six chapters. Bivariate extension of
Burr system is the subject matter of Chapter II. The author proposes to introduce a general structure for the family in two dimensions and present some properties of such a system. Also in Chapter II some new distributions, which are bivariate
extension of univariate distributions in Burr (1942) is presented.. In Chapter III, concentrates on characterization problems of different forms of bivariate Burr system. A detailed study of the distributional properties of each member of the
Burr system has not been undertaken in literature. With this aim in mind in Chapter
IV is discussed with two forms of bivariate Burr III distribution. In Chapter V the author Considers the type XII, type II and type IX distributions.
Present work concludes with Chapter VI by pointing out the multivariate
extension for Burr system. Also in this chapter the concept of
multivariate reversed hazard rates as scalar and vector quantity is introduced.
Description:
Department of Statistics, Cochin University of Science and Technology
Nandhu, M S; Dr. Paulose, C S(Cochin University of Science and Technology, March , 2011)
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Abstract:
Parkinson's disease is a chronic progressive neurodegenerative movement
disorder characterized by a profound and selective loss of nigrostriatal dopaminergic
neurons. Our findings demonstrated that glutamatergic system is impaired during PD.
The evaluations of these damages have important implications in understanding the
molecular mechanism underlying motor, cognitive and memory deficits in PD. Our
results showed a significant increase of glutamate content in the brain regions of 6-
OHDA infused rat compared to control. This increased glutamate content caused an
increase in glutamatergic and NMDA receptors function. Glutamate receptor
subtypes- NMDAR1, NMDA2B and mGluR5 have differential regulatory role in
different brain regions during PD. The second messenger studies confirmed that the
changes in the receptor levels alter the IP3, cAMP and cGMP content. The alteration
in the second messengers level increased the expression of pro-apoptotic factors - Bax
and TNF-α, intercellular protein - α-synuclein and reduced the expression of
transcription factor - CREB. These neurofunctional variations are the key contributors
to motor and cognitive abnormalities associated with PD. Nestin and GFAP
expression study confirmed that 5-HT and GABA induced the differentiation and
proliferation of the BMC to neurons and glial cells in the SNpc of rats. We also
observed that activated astrocytes are playing a crucial role in the proliferation of
transplanted BMC which makes them significant for stem cell-based therapy. Our
molecular and behavioural results showed that 5-HT and GABA along with BMC
potentiates a restorative effect by reversing the alterations in glutamate receptor
binding, gene expression and behaviour abnormality that occur during PD. The
therapeutic significance in Parkinson’s disease is of prominence.
Description:
Department of Biotechnology, Cochin University of
Science and Technology
Susha,D; Thrivikraman,T(Cochin University of Science and Technology, September , 2004)
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The topology as the product set with a base chosen as all products of open sets in the individual spaces. This topology is known as box topology. The main objective of this study is to extend the concept of box products to fuzzy box products and to obtain some results regarding them. Owing to the fact that box products have plenty of applications in uniform and covering properties, here made an attempt to explore some inter relations of fuzzy uniform properties and fuzzy covering properties in fuzzy box products. Even though the main focus is on fuzzy box products, some brief sketches regarding hereditarily fuzzy normal spaces and fuzzy nabla product is also provided.
The main results obtained include characterization of fuzzy Hausdroffness and fuzzy regularity of box products of fuzzy topological spaces. The investigation of the completeness of fuzzy uniformities in fuzzy box products proved that a fuzzy box product of spaces is fuzzy topologically complete if each co-ordinate space is fuzzy topologically complete. The thesis also prove that the fuzzy box product of a family of fuzzy α-paracompact spaces is fuzzy topologically complete. In Fuzzy box product of hereditarily fuzzy normal spaces, the main result obtained is that if a fuzzy box product of spaces is hereditarily fuzzy normal ,then every countable subset of it is fuzzy closed. It also deals with the notion of fuzzy nabla product of spaces which is a quotient of fuzzy box product. Here the study deals the relation connecting fuzzy box product and fuzzy nabla product
Chameswary, J; Dr.Sebastian, M T; Dr.Ananthakumar, S(Cochin University of Science and Technology, May , 2014)
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Abstract:
The first chapter of the thesis gives a general introduction about flexible electronics, dielectrics and composites. The recent developments in flexible electronics also discussed in this chapter. The preparation and characterization techniques used for the butyl rubber ceramic composites are given in chapter 2. The synthesis and characterization of butyl rubber filled with low permittivity ceramic composites are described in chapter 3. The chapter 4 deals with the synthesis and characterization of butyl rubber-high permittivity ceramic composites. The effect of high permittivity ceramic fillers such as TiO2, Sr2Ce2Ti5O15 and SrTiO3 on dielectric, thermal and mechanical properties was studied. The present investigation deals with synthesis, characterization and properties of butyl rubber composites with low, high and very high ceramic fillers and also the effect of particle size on dielectric, thermal and mechanical properties of selected composites.
Vinayakan, R; Dr. George Thomas, K(National Institute for Interdisciplinary Science and Technology,CSIR, May , 2009)
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Abstract:
The overall focus of the thesis involves the synthesis and
characterization of CdSe QDs overcoated with shell materials for various
biological and chemical sensing applications. Second chapter deals with the
synthesis and characterization of CdSe and CdSe/ZnS core shell QDs. The
primary attention of this work is to develop a simple method based on
photoinduced charge transfer to optimize the shell thickness. Synthesis of
water soluble CdSe QDs, their cytotoxicity analysis and investigation of
nonlinear optical properties form the subject of third chapter. Final chapter
deals with development of QD based sensor systems for the selective
detection of biologically and environmentally important analytes from
aqueous media.
Reni, George; Dr.Sugunan, S(Cochin University of Science And Technology, May , 2013)
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Abstract:
Mesoporous silica nanoparticles provide a non-invasive and biocompatible
delivery platform for a broad range of applications in therapeutics, pharmaceuticals
and diagnosis. Additionally, mesoporous silica materials can be synthesized
together with other nanomaterials to create new nanocomposites, opening up a
wide variety of potential applications. The ready functionalization of silica
materials makes them ideal candidates for bioapplications and catalysis. These
properties of mesoporous silica like high surface areas, large pore volumes and
ordered pore networks allow them for higher loading of drugs or biomolecules.
Comparative studies have been made to evaluate the different procedures;
much of the research to date has involved quick exploration of new methods
and supports. Requirements for different enzymes may vary, and specific
conditions may be needed for a particular application of an immobilized
enzyme such as a highly rigid support.
In this endeavor, mesoporous silica materials having different pore size
were synthesized and easily modified with active functional groups and were
evaluated for the immobilization of enzymes. In this work, Aspergillus niger
glucoamylase, Bovine liver catalase, Candida rugosa lipase were immobilized
onto support by adsorption and covalent binding. The structural properties of
pure and immobilized supports are analyzed by various characterization
techniques and are used for different reactions of industrial applications.
Description:
Department of Applied Chemistry
Cochin University of Science and Technology