Deo Prabha, Vasant; Dr.Sridhar, C S(Cochin University of Science and Technology, 1980)
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Abstract:
RMS measuring device is a nonlinear device consisting of linear and
nonlinear devices. The performance of rms measurement is influenced by a number
of factors; i) signal characteristics, 2) the measurement technique used and
3) the device characteristics. RMS measurement is not simple, particularly when
the signals are complex and unknown. The problem of rms measurement on high
crest-factor signals is fully discussed and a solution to this problem is presented
in this thesis.
The problem of rms measurement is systematically analized and found
to have mainly three types of errors: (1) amplitude or waveform error 2) Frequency
error and (3) averaging error. Various rms measurement techniques are studied
and compared. On the basis of this study the rms -measurement is reclassified
three categories: (1) Wave-form-error-free measurement (2) High-frequncy-error
measurement and (3) Low-frequency error-free measurement. In modern digital
sampled-data systems the signals are complex and waveform-error-free rms
measurement is highly appreciated.
Among the three basic blocks of rms measuring device the squarer
is the most important one. A squaring technique is selected, that permits shaping
of the squarer error characteristic in such a way as to achieve waveform-errob
free rms measurement. The squarer is designed, fabricated and tested.
A hybrid rms measurement using an analog rms computing device and
digital display combines the speed of analog techniques and the resolution and
ease of measurement of digital techniques. An A/D converter is modified to perform
the square-rooting operation. A 10-V rms voltmeter using the developed rms detector
is fabricated and tested.
The chapters two, three and four analyse the problems involved in rms
measurement and present a comparative study of rms computing techniques and
devices. The fifth chapter gives the details of the developed rms detector that
permits wave-form-error free rms measurement. The sixth chapter, enumerates the
the highlights of the thesis and suggests a list of future projects
Description:
Department of Electronics, Cochin University of Science and Technology
Ramakrishnan, K; Dr. Balakrishnan, K G(Cochin University of Science & Technology, 1991)
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Abstract:
Remote Data acquisition and analysing systems
developed for fisheries and related environmental studies
have been reported. It consists of three units. The first
one namely multichannel remote data acquisition system is
installed at the remote place powered by a rechargeable
battery. It acquires and stores the 16 channel environmental
data on a battery backed up RAM. The second unit
called the Field data analyser is used for insitue display
and analysis of the data stored in the backed up RAM. The
third unit namely Laboratory data analyser is an IBM
compatible PC based unit for detailed analysis and interpretation
of the data after bringing the RAM unit to the
laboratory. The data collected using the system has been
analysed and presented in the form of a graph. The system
timer operated at negligibly low current, switches on the
power to the entire remote operated system at prefixed time
interval of 2 hours.Data storage at remote site on low power battery
backedupRAM and retrieval and analysis of data using PC are
the special i ty of the system. The remote operated system takes about 7 seconds including the 5 second stabilization
time to acquire and store data and is very ideal for remote
operation on rechargeable bat tery. The system can store
16 channel data scanned at 2 hour interval for 10 days on
2K backed up RAM with memory expansion facility for 8K RAM.
Description:
Department of Electronics,
Cochin University of Science and Technology
Dileeplal, J; Dr.Narayanan, K P(Cochin University of Science And Technology, August , 2012)
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Abstract:
Assembly job shop scheduling problem (AJSP) is one of the most complicated
combinatorial optimization problem that involves simultaneously scheduling the
processing and assembly operations of complex structured products. The problem
becomes even more complicated if a combination of two or more optimization
criteria is considered. This thesis addresses an assembly job shop scheduling
problem with multiple objectives. The objectives considered are to simultaneously
minimizing makespan and total tardiness.
In this thesis, two approaches viz., weighted approach and Pareto approach are
used for solving the problem. However, it is quite difficult to achieve an optimal
solution to this problem with traditional optimization approaches owing to the
high computational complexity. Two metaheuristic techniques namely, genetic
algorithm and tabu search are investigated in this thesis for solving the multiobjective
assembly job shop scheduling problems.
Three algorithms based on the two metaheuristic techniques for weighted
approach and Pareto approach are proposed for the multi-objective assembly job
shop scheduling problem (MOAJSP). A new pairing mechanism is developed for
crossover operation in genetic algorithm which leads to improved solutions and
faster convergence.
The performances of the proposed algorithms are evaluated through a set of test
problems and the results are reported. The results reveal that the proposed
algorithms based on weighted approach are feasible and effective for solving
MOAJSP instances according to the weight assigned to each objective criterion
and the proposed algorithms based on Pareto approach are capable of producing a
number of good Pareto optimal scheduling plans for MOAJSP instances.
Description:
Department of Ship Technology, Cochin University of Science And Technology
Renuka, T R; Paulose,C S(DEPARTMENT OF BIOTECHNOLOGY, June , 2003)
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Abstract:
The present work is an attempt to understand the role of acetylcholine
muscarinic M1 and M3 receptors during pancreatic regeneration and insulin
secretion. The work focuses on the changes in the muscarinic M1 and M3 receptors
in brain and pancreas during pancreatic regeneration. The effect of these receptor
subtypes on insulin secretion and pancreatic P-cell proliferation were studied in vitro
using rat primary pancreatic islet culture. Muscarinic Ml and M3 receptor kinetics
and gene expression studies during pancreatic regeneration and insulin secretion will
help to elucidate the role of acetylcholine functional regulation of pancreatic u-cell
proliferation and insulin secretion.The cholinergic system through muscarinic M1
and M3 receptors play an important role in the regulation of pancreatic (3-cell
proliferation and insulin secretion . Cholinergic activity as indicated by acetylcholine
esterase, a marker for cholinergic system, decreased in the brain regions -
hypothalamus, brain stem, corpus striatum, cerebral cortex and cerebellum during
pancreatic regeneration. Pancreatic muscarinic M1 and M3 receptor activity increased during proliferation indicating that both receptors are stimulatory to (3-cell division. Acetylcholine dose dependently increase EGF induced DNA synthesis in pancreatic islets in vitro, which is inhibited by muscarinic antagonist atropine confirming the role of muscarinic receptors. Muscarinic M1 and M3 receptor antagonists also block acetycholine induced DNA synthesis suggesting the importance of these receptors in regeneration. Acetylcholine also stimulated glucose induced insulin secretion in vitro which is inhibited by muscarinic M1 and M3 receptor antagonists. The muscarinic receptors activity and their functional balance in the brain and pancreas exert a profound influence in the insulin secretion and also regeneration of pancreas
Savitha, Balakrishnan; Dr. Paulose, C S(Cochin University of Science and Technology, January , 2008)
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Abstract:
The present study describes that acetylcholine through muscarinic Ml and
M3 receptors play an important role in the brain function during diabetes as a function
of age. Cholinergic activity as indicated by acetylcholine esterase, a marker for
cholinergic function, decreased in the brain regions - the cerebral cortex, brainstem
and corpus striatum of old rats compared to young rats. in diabetic condition, it was
increased in both young and old rats in cerebral cortex, and corpus striatum while in
brainstem it was decreased. The functional changes in the muscarinic receptors were
studied in the brain regions and it showed that muscarinic M I receptors of old rats
were down regulated in cerebral cortex while in corpus striatum and brainstem it was
up regulated. Muscarinic M3 receptors of old rats showed no significant change in
cerebral cortex while in corpus striatum and brainstem muscarinic receptors were
down regulated. During diabetes, muscarinic M I receptors were down regulated in
cerebral cortex and brainstem of young rats while in corpus striatum they were up
regulated. In old rats, M I receptors were up regulated in cerebral cortex, corpus
striatum and in brainstem they were down regulated. Muscarinic M3 receptors were
up regulated in cerebral cortex and brainstem of young rats while in corpus striatum
they were down regulated. In old rats, muscarinic M l receptors were up regulated in
cerebral cortex, corpus striatum and brainstem. In insulin treated diabetic rats the
activity of the receptors were reversed to near control. Pancreatic muscarinic M3
receptor activity increased in the pancreas of both young and old rats during diabetes.
In vitro studies using carbachol and antagonists for muscarinic Ml and M3 receptor
subtypes confirmed the specific receptor mediated neurotransmitter changes during
diabetes. Calcium imaging studies revealed muscarinic M I mediated Ca2
+ release
from the pancreatic islet cells of young and old rats. Electrophysiological studies
using EEG recording in young and old rats showed a brain activity difference during diabetes. Long term low dose STH and INS treated rat brain tissues were used for
gene expression of muscarinic Ml, M3, glutamate NMDARl, mGlu-5,alpha2A, beta2,
GABAAa1 and GABAB, DAD2 and 5-HT 2C receptors to observe the neurotransmitter
receptor functional interrelationship for integrating memory, cognition and
rejuvenating brain functions in young and old. Studies on neurotransmitter receptor
interaction pathways and gene expression regulation by second messengers like IP3
and cGMP in turn will lead to the development of therapeutic agents to manage
diabetes and brain activity.From this study it is suggested that functional improvement of
muscarinic Ml, M3, glutamate NMDAR1, mGlu-5, alpha2A, beta2, GABAAa1 and GABAB,
DAD2 and 5-HT 2C receptors mediated through IP3 and cGMP will lead to therapeutic
applications in the management of diabetes. Also, our results from long term low dose
STH and INS treatment showed rejuvenation of the brain function which has clinical
significance in maintaining healthy period of life as a function of age.
Description:
Department of Biotechnology,
Cochin University of Science and Technology
Sherin, Antony; Dr. Paulose, C S(Cochin University of Science & Technology, May , 2010)
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Abstract:
In the present study, a detailed investigation on the alterations of
muscarinic M1, M3, α7 nicotinic acetylcholine receptor (α7 nAchR), GABA
receptors and its subtypes; GABAAα1 and GABAB in the brain regions of
streptozotocin induced diabetic and insulin induced hypoglycemic rats were
carried out. Gene expression of acetylcholine esterase (AChE), choline
acetyltransferase (ChAT), GAD, GLUT3, Insulin receptor, superoxide dismutase
(SOD), Bax protein, Phospholipase C and CREB in hypoglycemic and
hyperglycemic rat brain were studied. Muscarinic M1, M3 receptors, AChE,
ChAT, GABAAα1, GABAB, GAD, Insulin receptor, SOD, Bax protein and
Phospholipase C expression in pancreas was also carried out. The molecular
studies on the CNS and PNS damage will elucidate the therapeutic role in the
corrective measures of the damage to the brain during hypoglycemia and
hyperglycemia.
Description:
Department of Biotechnology,Cochin University of Science and Technology
Gireesh,G; Dr. Paulose, C S(Cochin University of Science & Technology, January , 2007)
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Abstract:
The present work is to understand the alterations of total Muscarinic and
Muscarinic MI receptors in brain and pancreatic islets of Streptozotocin induced
diabetic rats. The work focuses on the evaluation of the antihyperglycemic activity
of aqueous extracts of Aegle marmelose and Costus pictus leaves in vivo and the
changes in the total Muscarinic and Muscarinic MI receptors during diabetes and
after the treatment with insulin. The insulin secretory activity of Aegle marmelose
and Costus pictus leaf extracts and the effect of cholinergic receptor agonist were
investigated in vitro using rat primary pancreatic islet culture. Muscarinic MI
receptor kinetics and gene expression during diabetes and regulation of insulin
secretion by Aegle marmelose and Costus pie/us leaf extracts will help us to
elucidate the role of Muscarinic and Muscarinic MI receptors in hyperglycemia
and the regulatory activity of these plant extracts on insulin secretion through
Muscarinic receptors.
Description:
Department of
Biotechnology, Cochin University of Science and Technology
Reas Khan, S; Dr. Paulose, C S(Cochin University of Science and Technology, April , 2007)
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Abstract:
The present work is to understand the alterations of total muscarinic.
muscarinic MI and glutamate receptors in the brain regions of pilocarpine induced
epileptic rats. The work focuses on the evaluation of the anti epileptic activity of
extracts of Bacopa monnieri, Bacoside A and Carbamazepine in vivo. The
molecular changes in the muscarinic M I receptors in the pre- and post-treated
epileptic model with Bacopa monnieri, Bacoside A and Carbamazepine were also
studied. These studies will help us to elucidate the functional role of muscarinic
and glutamate receptors in epilepsy.
Description:
Department of Biotechnology, Cochin University of
Science and Technology
Vineetha K.A; Dr. Ajitha, K(Cochin University of Science and Technology, November 6, 2015)
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Abstract:
िशक्षा एवं जागरण के फलस्वरूप आधुिनक समाज म नारी िविभ क्षेतर्ो म
उपलिब्धयाँ हािसल करने लगी है| वह हर क्षेतर् म पुरुष के साथ कंधे से कन्धा िमलाकर
आगे बढ़ने की कोिशश कर रही है| पर िपतृसा भी हर युग म अपना वचर्स्व बनाये
रखने की कोिशश करती आ रही है| वह ी को हमेशा दूसरे दज के नागिरक के रूप म
मानती है| वह नारी की गित पर रोक लगाने का पर्यास करती रहती है क्यिक उसके
स्वाथ की पूित के िलए यह अिनवायर् है| आज़ादी के इतने वषर् बीतने पर भी नारी की
िस्थित म अनेकानेक िवडंबनाय िदखाई पड रही ह| भूमंडलीकरण भी उसे यौन िसबंल
के रूप म पिरवितत कर रहा है|
Ramakrishnan, R; Dr. Manoj Raama Varma; Dr. J. D. Sudha(Cochin University of Science and Technology, July 25, 2014)
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Abstract:
Recent developments on nanostructured conducting polymer-inorganic
composites systems have receieved considerable research interest owing to their
unique synergestic properties compared with their individual bulk counter parts
which make them promising candidates for a broad spectrum of high technological
applications such as in energy conversion, electronic devices, storage, sensors,
actuators, memory devices, and biomedical devices. Nanostructured conducting
polymers possess unique features such as high specific surface area, high charge
carrier concentration, high electrical conductivity, high mechanical flexibility, light
weight, solution processability and printability over a large area which make them
favourable for their high tech applications. Among the conducting polymers,
polyanilline, poly(3,4-ethylene dioxy thiophene), poly(N-vinylcarbzole) are
receiving much importance due to their low cost, environmental stability and
unique doping mechanism. Conversely, semiconducting inorganic metal oxide such
as zinc oxide and titania nanomaterials have emerged as an area of intense research
interest motivated by their potential applications in electronics, non-linear optics,
and magnetic devices due to their low band gap, small crystalline size and unique
opto-electronic properties. In this perspective, studies on the development and
applications of semiconducting polymer-inorganic metal oxide nanocomposite are
interesting since it is expected to exhibit synergistic properties arising from the
molecular level mixing of conducting polymer and inorganic counter parts.