Roshini, Thumpakara K; Dr.Prathapan, S(Cochin University of Science & Technology, November , 2007)
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Abstract:
The synthesis and reactions of simple derivatives of 2(3H)- and 3(2H)furanones
have attracted considerable attention in recent years, primarily in
connection with development of routes to antitumor agents that contain this
ring as central structural unit. They also serve as useful synthetic building
blocks for lactones and furans and are the precursors of a wide variety of
biologically important heterocyclic systems. Although a number of syntheses
of furanones were known they were in many cases limited to specific
substitution pattems. The development of altemative strategies for the
preparation of these heterocycles is therefore of considerable importance or
continues to be a challenge.We propose to develop new and general approaches to the synthesis of
furanone ring systems from simple and readily available starting materials
since we were interested in examining their rich photochemistry. The
photochemical reactivity of Beta,gama-unsaturated lactams and lactones is a subject of current interest. Some of the prominent photoreaction pathways of
unsaturated lactones include decarbonylation, solvent addition to double
bonds, decarboxylation, migration of aryl substituents and dimerisation. lt
was reported earlier that the critical requirement for clean photochemical
cleavage of the acyl-oxygen bond is the presence ofa double bond adjacent to
the ether oxygen and 2(3H)-furanones possessing this structural requirement
undergo facile decarbonylation. But related phenanthrofuranones are isolated
as photostable end products upon irradiation. Hence we propose to synthesis a
few phenanthro-2(3H)-furanones to study the effect of a radical stabilising
group at 3-position of furanone ring on photolysis. To explore the tripletmediated
transformations of 2(3H)-furanones in polar and nonpolar solvents a
few 3,3-bis(4-chlorophenyl)-5-aryl-3H-furan-2-ones and 3,3-di(p-tolyl)-5-aryl-
3H-furan-2-ones were synthesised from the corresponding
dibenzoylstyrene precursors by neat thermolysis. Our aim was to study the
nature of intermediates involved in these transformations.We also explored the possibility of developing a new and general
approach to the synthesis of 3(2H)-furanones from simple and readily
available starting materials since such general procedures are not available.
The protocol developed by us employs readily available phenanthrenequinone
and various 4-substituted acetophenones as starting materials and provides
easy access to the required 3(2H)-furanone targets. These furanone
derivatives have immense potential for further investigations .We also aimed the synthesis of a few dibenzoylalkene-type systems
such as acenaphthenone-2—ylidene ketones and phenanthrenone-9-ylidene
ketones. These systems were expected to undergo thermal rearrangement to
give furanones and spirofuranones. Also these systems can be categorised as
quinonemethides which are valuable synthetic intermediates.
Description:
Department of Applied Chemistry, Cochin University of Science
and Technology
Pyroja, S; Paulose,C S(Department of Biotechnology, Faculty of Science, April , 2002)
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Abstract:
The work is an attempt to understand the role of 5-HT, 5-HT1A and 5-HT2C receptors in the regulation of liver cell proliferation using in vivo and in vitro models. The work also focuses on the brain serotonergic changes associated with hapatocyte proliferation and apoptosis to delineate its regulatory function. The investigation of mechanisms involving different models of hepatocyte proliferation contributes to our knowledge about serotonergic regulation of cell growth, apoptosis and carcinogenesis of liver. The study reveals that the alteration of the 5-HT1A and 5-HT2C receptor function and gene expression in the brain stem, cerebral cortex and hypothalamus play an important role in the sympathetic regulation of cell proliferation, neoplastic transformation and apoptosis. The functional balance between 5-HT1A and 5-HT2C receptor plays an important role in regulating hepatocyte proliferation, neoplastic transformation and hepatic apoptosis. The regulatory role of 5-HT1A and 5-HT2C receptor during neoplastic transformation and apoptosis could lead to possible therapeutic intervention in the treatment of cancers and have immense clinical importance.
Baby,Jacob; Dr.Sankaranarayanan, K C(Cochin University of Science and Technology, March 1, 1985)
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Abstract:
An attempt is made to identify the causes for the decline of Kerala’s agricultural export performance. The study evaluates the policies of the government and programmes of the organization assigned with the task of development of export trade of specific commodities. The researcher recommends a plan of action with long term perspective and suggests appropriate strategies for the export development of the traditional and nontraditional agricultural items. T he thesis also review trends in the world trade of the major exports from Kerala
Description:
Department of Applied Economics, Cochin University of Science and Technology
Anil,R Nair; Dr.Sadasivan Nair,G(Cochin University Of Science And Technology, October 20, 2009)
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Abstract:
Access to education becomes an issue of equity with diverse
claims from stakeholders justifying their rights based on perceptions
of equity — both social and individual. In-spite of the phenomenal
increase since independence in the number of institutions imparting
education and the number of beneficiaries, India being the second
largest nation in terms of population of the young finds its resources
spread thin in meeting the demand for education. Quality education
comes at a premium in India whether it is provided in the private or
in the public sector. Education seemingly enables the individuals,
singly and collectively. to overcome the social barriers perpetuated
by the caste system. Taken together, these unleash grave demands on formulating equitable standards. It is in this context that
identifying the deserving for favourable consideration becomes all
the more important.
In this sea of claims and counter-claims, this thesis tries to
identify the issues involved on the question of equitable access to
education on the basis of the factual position in the field of
education. Identifying the issues correctly provides the necessary
impetus for framing the questions that provide meaningful answers.
The objective of this research is to help formulate the policy
guidelines governing the principles of equity that is needed to
ensure universal access to education in India.
Description:
School of Legal Studies, Cochin University of Science and
Technology
Binsy,Varghese V; Dr.Sugunan, S(Cochin University Of Science And Technology, February , 1998)
[+]
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Abstract:
Catalysis research underpins the science of modern chemical processing
and fuel technologies. Catalysis is commercially one of the most important
technologies in national economies. Solid state heterogeneous catalyst materials such
as metal oxides and metal particles on ceramic oxide substrates are most common.
They are typically used with commodity gases and liquid reactants. Selective oxidation
catalysts of hydrocarbon feedstocks is the dominant process of converting them to key
industrial chemicals, polymers and energy sources.[1]
In the absence of a unique successfiil theory of heterogeneous catalysis,
attempts are being made to correlate catalytic activity with some specific properties of
the solid surface. Such correlations help to narrow down the search for a good catalyst
for a given reaction.
The heterogeneous catalytic performance of material depends on many
factors such as [2]
Crystal and surface structure of the catalyst.
Thermodynamic stability of the catalyst and the reactant.
Acid- base properties of the solid surface.
Surface defect properties of the catalyst.Electronic
and semiconducting properties and the band structure.
Co-existence of dilferent types of ions or structures.
Adsorption sites and adsorbed species such as oxygen.Preparation method of catalyst , surface area and nature of heat treatment.
Molecular structure of the reactants.
Many systematic investigations have been performed to correlate
catalytic performances with the above mentioned properties. Many of these
investigations remain isolated and further research is needed to bridge the gap in the
present knowledge of the field.
Description:
Department of Applied Chemistry, Cochin University of Science & Technology
Jasmine, Mathew; Dr. Ebenezer, D D(Defence Research and Development Organisation, September , 2011)
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Abstract:
New mathematical methods to analytically investigate linear acoustic radiation
and scattering from cylindrical bodies and transducer arrays are presented. Three
problems of interest involving cylinders in an infinite fluid are studied. In all the three
problems, the Helmholtz equation is used to model propagation through the fluid and the
beam patterns of arrays of transducers are studied.
In the first problem, a method is presented to determine the omni-directional and
directional far-field pressures radiated by a cylindrical transducer array in an infinite
rigid cylindrical baffle. The solution to the Helmholtz equation and the displacement
continuity condition at the interface between the array and the surrounding water are
used to determine the pressure. The displacement of the surface of each transducer is in
the direction of the normal to the array and is assumed to be uniform. Expressions are
derived for the pressure radiated by a sector of the array vibrating in-phase, the entire
array vibrating in-phase, and a sector of the array phase-shaded to simulate radiation
from a rectangular piston. It is shown that the uniform displacement required for
generating a source level of 220 dB ref. μPa @ 1m that is omni directional in the
azimuthal plane is in the order of 1 micron for typical arrays. Numerical results are
presented to show that there is only a small difference between the on-axis pressures
radiated by phased cylindrical arrays and planar arrays. The problem is of interest
because cylindrical arrays of projectors are often used to search for underwater objects.
In the second problem, the errors, when using data-independent, classical, energy
and split beam correlation methods, in finding the direction of arrival (DOA) of a plane
acoustic wave, caused by the presence of a solid circular elastic cylindrical stiffener near
a linear array of hydrophones, are investigated. Scattering from the effectively infinite
cylinder is modeled using the exact axisymmetric equations of motion and the total
pressures at the hydrophone locations are computed. The effect of the radius of the
cylinder, a, the distance between the cylinder and the array, b, the number of
hydrophones in the array, 2H, and the angle of incidence of the wave, α, on the error in
finding the DOA are illustrated using numerical results. For an array that is about 30
times the wavelength and for small angles of incidence (α<10), the error in finding the
DOA using the energy method is less than that using the split beam correlation method
with beam steered to α; and in some cases, the error increases when b increases; and the errors in finding the DOA using the energy method and the split beam correlation
method with beam steered to α vary approximately as a7 / 4 . The problem is of interest
because elastic stiffeners – in nearly acoustically transparent sonar domes that are used to
protect arrays of transducers – scatter waves that are incident on it and cause an error in
the estimated direction of arrival of the wave.
In the third problem, a high-frequency ray-acoustics method is presented and
used to determine the interior pressure field when a plane wave is normally incident on a
fluid cylinder embedded in another infinite fluid. The pressure field is determined by
using geometrical and physical acoustics. The interior pressure is expressed as the sum
of the pressures due to all rays that pass through a point. Numerical results are presented
for ka = 20 to 100 where k is the acoustic wavenumber of the exterior fluid and a is the
radius of the cylinder. The results are in good agreement with those obtained using field
theory. The directional responses, to the plane wave, of sectors of a circular array of
uniformly distributed hydrophones in the embedded cylinder are then computed. The
sectors are used to simulate linear arrays with uniformly distributed normals by using
delays. The directional responses are compared with the output from an array in an
infinite homogenous fluid. These outputs are of interest as they are used to determine the
direction of arrival of the plane wave. Numerical results are presented for a circular array
with 32 hydrophones and 12 hydrophones in each sector. The problem is of interest
because arrays of hydrophones are housed inside sonar domes and acoustic plane waves
from distant sources are scattered by the dome filled with fresh water and cause
deterioration in the performance of the array.
Deepthi, Augustine; Dr.Rosamma, Philip(Cochin University of Science And Technology, May , 2014)
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Abstract:
The thesis is comprised of seven chapters. Chapter 1 gives a general introduction to marine actinomycetes; Chapter 2 gives an account on the morphological, biochemical and physiological characterization of marine actinomycetes. Comprehensive description of molecular identification and phylogenetic analysis of actinomycetes is dealt with in Chapter 3. The antimicrobial property with special reference to antivibrio activity is described in Chapter 4. Chapter 5 explores the melanin production ability of marine actinomycetes, characterization of melanin and evaluation of its bioactivity. Chapter 6 illustrates the study on chitinolytic Streptomyces as antifungal and insecticidal agents. Summary and Conclusion of the study is presented in Chapter 7, followed by References and Appendices.The present study provides an insight into the various actinomycetes occurring in the sediments of Arabian Sea and Bay of Bengal. Streptomyces was found to be the dominant group followed by Nocardiopsis. Eventhough generic level identification is possible by traditional phenotypic methods, species level identification necessitate a polyphasic approach including both phenotypic and genotypic characterization. Antibiotic production coupled with biogranulation property helped in the effective utilization of the actinomycetes for the control of vibrios. Melanin from Streptomyces bikiniensis was proved to be a promising antioxidant and photoprotectant. Marine actinomycetes were found to be a good source of hydrolytic enzymes and the chitinolytic isolates could be explored as biocontrol agents in terms of antifungal and insecticidal property. The present study explored the potential of marine actinomycetes especially Streptomycetes as a promising source of bioactive molecules for application in aquaculture and pharmaceutical industry.
Varkey, A M; Dr.Sebastian, V D(Cochin University of Science and Technology, March 2, 1984)
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Abstract:
The joint stock company is an institution wielding immense socio economic _power over the ultimate progress and well -being of the nation. It is subjected to corresponding definable responsibilities towards all who depend on than. the shareholders.the employees the suppliers of raw materials. the consumers of its product: and society at Large. The company law is changing and must change with time and take note of the dynamics of trade and industry. Obviously it cannot be static and permanent while the basic economic and social philosophies and the technique of production and investment in the industrial sector change.‘ It provides a legal framework for the corporate form of business in which the organization capital and labour are brought. together in a particular form of relationship. The activities carried on within this corporate form is subjected to a gradual but steadily increasing control by the Government. A study of this oontrol is undertaken to better understand the present law and to suggest the path for further change
Description:
Department of Law, Cochin University of Science and Technology
Finla, Chathu; Dr. Paulose, C S(Cochin University of Science and Technology, February , 2007)
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Abstract:
In the present work, the role of oxygen, epinephrine and glucose
supplementation in regulating neurotransmitter contents, adrenergic and glutamate
receptor binding parameters in the cerebral cortex of experimental groups of neonatal
rats were investigated. The study of neurotransmitters and their receptors in the
cerebral cortex and the EEG pattern in the brain regions of neonatal rats were taken as
index for brain damage due to hypoxia, oxygen and epinephrine. Real-Time PCR work was done to confirm the binding parameters. Second messenger, cyclic
Adenosine Monophosphate (cAMP) was assayed to find the functional correlation of
the receptors. Behavioural studies were carried out to confirm the biochemical and
molecular studies. The efficient and timely supplementation of glucose plays a crucial
role in correcting the molecular changes due to hypoxia, oxygen and epinephrine. The
addictive neuronal damage effect due to oxygen and epinephrine treatment is another
important observation. The corrective measures from the molecular study brought to
practice will lead to maintain healthy intellectual capacity during the later
developmental stages, which has immense clinical significance in neonatal care.
Description:
Department of Biotechnology, Cochin
University of Science and Technology
Naijil, George; Dr.Paulose, C S(Cochin University of Science and Technology, May 14, 2014)
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Abstract:
In the present study, the initial phase was directed to confirm the effects of
curcumin and vitamin D3 in preventing or delaying diabetes onset by studying the
blood glucose and insulin levels in the pre-treated and diabetic groups.
Behavioural studies were conducted to evaluate the cognitive and motor function
in experimental rats. The major focus of the study was to understand the cellular
and neuronal mechanisms that ensure the prophylactic capability of curcumin and
vitamin D3. To elucidate the mechanisms involved in conferring the antidiabetogenesis
effect, we examined the DNA and protein profiles using
radioactive incorporation studies for DNA synthesis, DNA methylation and
protein synthesis. Furthermore the gene expression studies of Akt-1, Pax, Pdx-1,
Neuro D1, insulin like growth factor-1 and NF-κB were done to monitor pancreatic beta cell proliferation and differentiation. The antioxidant and antiapoptotic
actions of curcumin and vitamin D3 were examined by studying the
expression of antioxidant enzymes - SOD and GPx, and apoptotic mediators like
Bax, caspase 3, caspase 8 and TNF-α. In order to understand the signalling
pathways involved in curcumin and vitamin D3 action, the second messengers,
cAMP, cGMP and IP3 were studied along with the expression of vitamin D
receptor in the pancreas. The neuronal regulation of pancreatic beta cell
maintenance, proliferation and insulin release was studied by assessing the
adrenergic and muscarinic receptor functional regulation in the pancreas, brain
stem, hippocampus and hypothalamus. The receptor number and binding affinity
of total muscarinic, muscarinic M1, muscarinic M3, total adrenergic, α adrenergic
and β adrenergic receptor subtypes were studied in pancreas, brain stem and
hippocampus of experimental rats. The mRNA expression of muscarinic and
adrenergic receptor subtypes were determined using Real Time PCR.
Immunohistochemistry studies using confocal microscope were carried out to
confirm receptor density and gene expression results. Cell signalling alterations in
the pancreas and brain regions associated with diabetogenesis and antidiabetogenesis
were assessed by examining the gene expression profiles of
vitamin D receptor, CREB, phospholipase C, insulin receptor and GLUT. This
study will establish the anti-diabetogenesis activity of curcumin and vitamin D3
pre-treatment and will attempt to understand the cellular, molecular and neuronal
control mechanism in the onset of diabetes.Administration of MLD-STZ to curcumin and
vitamin D3 pre-treated rats
induced only an incidental prediabetic condition. Curcumin and vitamin D3 pretreated
groups injected with MLD-STZ exhibited improved circulating insulin
levels and behavioural responses when compared to MLD-STZ induced diabetic
group. Activation of beta cell compensatory response induces an increase in
pancreatic insulin output and beta cell mass expansion in the pre-treated group.
Cell signalling proteins that regulate pancreatic beta cell survival, insulin release,
proliferation and differentiation showed a significant increase in curcumin and
vitamin D3 pre-treated rats. Marked decline in α2 adrenergic receptor function in
pancreas helps to relent sympathetic inhibition of insulin release. Neuronal
stimulation of hyperglycemia induced beta cell compensatory response is
mediated by escalated signalling through β adrenergic, muscarinic M1 and M3
receptors. Pre-treatment mediated functional regulation of adrenergic and
cholinergic receptors, key cell signalling proteins and second messengers
improves pancreatic glucose sensing, insulin gene expression, insulin secretion,
cell survival and beta cell mass expansion in pancreas. Curcumin and vitamin D3
pre-treatment induced modulation of adrenergic and cholinergic signalling in brain
stem, hippocampus and hypothalamus promotes insulin secretion, beta cell
compensatory response, insulin sensitivity and energy balance to resist
diabetogenesis. Pre-treatment improved second messenger levels and the gene
expression of intracellular signalling molecules in brain stem, hippocampus and
hypothalamus, to retain a functional neuronal response to hyperglycemia.
Curcumin and vitamin D3 protect pancreas and brain regions from oxidative stress
by their indigenous antioxidant properties and by their ability to stimulate cellular
free radical defence system. The present study demonstrates the role of adrenergic
and muscarinic receptor subtypes functional regulation in curcumin and vitamin
D3 mediated anti-diabetogenesis. This will have immense clinical significance in
developing effective strategies to delay or prevent the onset of diabetes.
Sudha, B; Dr. Paulose, C S(Cochin University of Science And Technology, March , 1997)
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Abstract:
The adult mammalian liver is predominantly in a quiescent state with respect to cell
division. This quiescent state changes dramatically, however, if the liver is injured by
toxic, infectious or mechanic agents (Ponder, 1996). Partial hepatectomy (PH) which
consists of surgical removal of two-thirds of the liver, has been used to stimulate
hepatocyte proliferation (Higgins & Anderson 1931). This experimental model of liver
regeneration has been the target of many studies to probe the mechanisms responsible for
liver cell growth control (Michalopoulos, 1990; Taub, 1996). After PH most of the
remaining cells in the renmant liver respond with co-ordinated waves of DNA synthesis
and divide in a process called compensatory hyperplasia. Hence, liver regeneration is a
model of relatively synchronous cell cycle progression in vivo. In contrast to hepatomas,
cell division is terminated under some intrinsic control when the original cellular mass has
been regained. This has made liver regeneration a useful model to dissect the biochemical
and molecular mechanisms of cell division regulation. The liver is thus, one of the few
adult organs that demonstrates a physiological growth rewonse (Fausto & Mead, 1989;
Fausto & Webber, 1994). The regulation of liver cell proliferation involves circulating or
intrahepatic factors that are involved in either the priming of hepatocytes to enter the cell
cycle (Go to G1) or progression through the cell cycle. In order to understand the basis of
liver regeneration it is mandatory to define the mechanisms which (a) trigger division, (b)
allow the liver to concurrently grow and maintain dilferentiated fimction and (c) terminate
cell proliferation once the liver has reached the appropriate mass. Studies on these aspects
of liver regeneration will provide basic insight of cell growth and dilferentiation, liver
diseases like viral hepatitis, toxic damage and liver transplant where regeneration of the
liver is essential. In the present study, Go/G1/S transition of hepatocytes re-entering the
cell cycle after PH was studied with special emphasis on the involvement of
neurotransmitters, their receptors and second messenger function in the control of cell
division during liver regeneration
Description:
Department of Biotechnology, Cochin University of Science and Technology
Ani Das, V; Paulose,C S(Department of Biotechnology, Faculty of Science, August , 2000)
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Abstract:
In the present study, the changes in the brain EPI (Epinephrine), adrenergic receptors and the receptor gene expression were investigated during pancreatic regeneration and insulin secretion. The changes in the pancreatic islet EPI and adrenergic receptors were also studied in the pancreatectomised rats. The regulatory function of EPI in association with Epidermal growth factor (EGF) and glucose were investigated in rat islet cultures. In vitro studies were carried out using antagonists for adrenergic receptor subtypes to see their involvement in the islet DNA synthesis. The mechanism by which the peripheral EPI regulate insulin secretion was also investigated by studying the nuclear binding proteins in the pancreatic islets during pancreatic regeneration and diabetes. The study reveals that EPI can regulate the pancreatic islet cell proliferation by controlling the insulin synthesis and secretion. The brain adrenergic receptor gene expression and functional correlation regulate the pancreatic adrenergic receptors. The functional balance of α and β-adrenergic receptors controls the insulin secretion and pancreatic β-cell proliferation, which will have immense clinical significance in the treatment of Diabetes mellitus.
Asha,Abraham; Dr. Paulose, C S(Cochin University of Science And Technology, March 30, 1998)
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Abstract:
I) To study the changes in the content of brain rrrorroamirres in streptozotocirr-irrduced
tliabetes as a lirnction of age and to lirrd the role oliadrenal lrornroncs in diabetic state.
2) To assess the adrenergic receptor function in the brain stem ofstreptozotocin-induced
diabetic rats ofdillerent ages.
3) To study the changes in the basal levels of second messenger cAMP in the brain stenr
ofstreptozotocin-induced diabetic rats as a function of age.
4) To study the changes occurring in the content ofmorroamines and their metabolites in
whole pancreas and isolated pancreatic islets of streptozotocin-diabetic rats as a function
ofage and the effect of adrenal hormones.
5) To study the adrenergic receptors and basal levels of cAMP in isolated pancreatic islets
in young and old streptozotoein-diabetic rats.
6) The in virro study of CAMP content in pancreatic islets of young and old rats and its
ellect on glucose induced insulin secretion.
7) 'lhe in vitro study on the involvement of dopamine and corticosteroids in glucose
induced insulin secretion in pancreatic islets as a function of age.
Description:
Department of
Biotechnology, Cochin University of Science and Technology
Ancy, Sebastian; Dr.Mariamma Vincent, Panikulangara(Cochin University Of Science And Technology, March 1, 2014)
[+]
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Abstract:
The present study is entitled The Aesthetics of Paul Verlaine
and Changampuzha Krishnapillai - a comparative perspective. The
purpose of the study is to compare the poetic genius of the French poet Paul
Verlaine (1844-1896) and that of the Malayalam poet Changampuzha
Krishnapillai (1911-1948), within a descriptive framework. The
investigation will hopefully answer the questions-
Has Changampuzha been indeed influenced by Verlaine, if so, to what
extent? Can the aesthetic appreciation be justified in both poets as illustrated
in their works?
The comparative methodology of juxtaposing the selected oeuvres of
the poets is largely adopted in the study. Since the span of analysis is across
national and linguistic borders, the distinguishing as well as exclusive traits
of the individual poets will be of much importance in formulating the
comparative assumption in this work. The vastly differing geographical,
linguistic and cultural milieus of these two poets,-one a national French poet
and the other, a regional Indian poet writing in Malayalam prima facie,endow the theme of the dissertation with an innate hue of diversity. Such an
ambitious task would naturally entail a renewed research into the dedication
of the poets to their muses and their ultimate contributions to poetics. The
analysis, while attempting to illuminate from a fresh angle, the amply
researched oeuvre of Verlaine and the lesser studied one of Changampuzha,
cannot but be aware of the limitations of the task at hand. The present study
is the first of its kind on the specific theme of analysis, and is hoped that it
would be of relevance since no work has so far been known to have been
undertaken on the topic. At a time when the birth centenary celebrations of
Changampuzha have just concluded, this study is hoped to assume
significance as it would help in isolating the originality of the poet's works,
extricating the garb of the French influence. Ultimately, this study aims at
creating a wider appreciation of the impact that the French writers have had
on Malayalam writers, thus shedding new light on the benign foreign
influences that served to enhance the beauty of our cultural heritage
Description:
Department of English and Foreign Languages,
Cochin University of Science and Technology
The present study was undertaken to elucidate the nutritional and pathological changes associated with aflatoxin B1 toxicity in Penaeus monodon and to determine the efficacy of vitamins E and K, and Amrita Bindu, herbal mixture in ameliorating the toxicity of AFB1.
The main objectives the study is to document the pathological and immunological changes in P.monodon fed with AFB1 incorporated diets and to delineate the histological and ultrastructural changes and determine the presence of AFB1 residue in the shrimp body, to evaluate the growth performance of feed efficiency in P. monodon post larvae fed AFB1 added diets, to assess the interactive effect of heavy metals like copper and cadmium at sub-lethal levels in P. monodon postlarve fed AFB1 added diets, to decipher the ameliorative action of Vitamins E & K and a spicy herbal mixture, Amrita Bindu on AFB1 in P.monodon sub-adults. The study has revealed that Aflatoxin B1 significantly affects protein, lipid and carbohydrate metabolism in the shrimp penaeus monodon. The remarkable effect was observed in the immune system, as AFB1 has elevatod the immune response during initial days of exposure and prolonged exposure to the toxin leads to weakening of the animal’s immunity. Aflatoxin B1 level above 50 ppb severely affected the growth and feed utilization which in turn reflects the damage caused to the hepatopancreas as evident from the histological and ultrastructural observations.
Lekha,P V; Dr.Ram Mohan,H S(Cochin University of Science And Technology, May , 1992)
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Abstract:
Usually, under rainfed conditions the growing period exists
in the humid months. Hence, for agricultural planning knowledge
about the variabilities of the duration of the humid seasons are
very much needed. The crucial problem affecting agriculture is
the persistency in receiving a specific amount of rainfall during a short period. Agricultural operations and decision making are highly dependent on the probability of receiving given amounts of rainfall; such periods should match the water requirements of different phenological phases of the crops. While prolonged dry periods during sensitive phases are detrimental to their growth and lower the yields, excess of rainfall causes soil erosion and loss of soil nutrients. These factors point to the importance of evaluation of wet and dry spells. In this study the weekly rainfall data have been analysed to estimate the probability of wet and dry periods at all selected stations of each agroclimatic zone and the crop growth potentials of the growing seasons have been analysed. The thesis consists of six Chapters.
Description:
School of marine sciences, Cochin University of Science And Technology
Valsamma, Joseph; Dr.Ammini, Joseph(Cochin University of Science And Technology, April , 1998)
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Abstract:
The present research is based on two broader aspects of pollution assessment ,and
treatability of petroleum and petrochemical effluents by algae. The objectives of the investigation are to study the algal ecology and trophic status of an oil refinery effluent holding pond , isolate and identify pure cultures of algae, study the role of algae in petroleum and petrochemical effluent treatment, develop strains of algae tolerant to toxic effluents, study the biotreatment potential of the tolerant algal strains developed The thesis comprises of six chapters. The first chapter gives the significance and objectives of the present study. The second chapter describes the methodology, and results of studies on the algal ecology, and trophic status of the effluent holding pond of Cochin Refineries Ltd., Ambalamugal, Kochi. The third chapter deals with the isolation, and development of pure cultures of algae, the algal bioassay of the refinery effluent, and the analyses of Chitrapuzha river water. The analysis, and assessment of the algal growth potential of the petrochemical effluent of Hindustan Organic Chemicals Ltd., Ambalamugal, Kochi.
are summarised in the fourth chapter The fifth chapter deals with the algal growth potential in phenol and phenolic effluent, and subsequent absorption of phenol and total dissolved solids. The summary and conclusion of the present study are given in the sixth chapter.
Description:
Department of environmental studies, Cochin University of Science And Technology
Anit, Thomas M; Dr.Saramma, A V(Cochin University of Science And Technology, April , 2014)
[+]
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Abstract:
It is essential to understand how the distribution and composition of
microalgae as well as dynamics of HABs in economically important shelf seas
relate to the particular physico-chemical and biological properties of the water
column in which they live. In view of the importance of southwest coast of
India, which is considered as one of the most biologically productive areas in
the world, regular monitoring of distribution and abundance of microalgae
is important. The present work is concentrated on the estuarine and coastal
open sea stations along the southwest coast of India. In order to get further
insights into the abiotic factors governing bloom dynamics, the physicochemical
parameters that regulated three particular bloom events during
this period were studied. Bearing in mind the role of bacterial fauna
associated with algal blooms as a biological factor in regulating its
dynamics, isolation of bacteria associated with the algal blooms, their
identification, enumeration, and ability to produce extracellular enzymes
have been duly incorporated into this study
Description:
Department of Marine Biology, Microbiology and Biochemistry
School of Marine Sciences
Cochin University of Science and Technology