Remya, Robinson; Dr. Paulose, C S(Cochin University of Science and Technology, April , 2007)
[+]
[-]
Abstract:
In the present study a detailed investigation on the alterations of dopamine
and its receptors in the brain regions of streptozotocin induced diabetic and insulin
induced hypoglycaemic rats were carried out. Glutamate receptor, NMDARI gene
expression in the hypoglycaemic and hyperglycaemic brain was also studied. EEG
recording in hypoglycaemic and hyperglycaemic will be carried out to measure brain
activity. in vitro studies on glucose uptake and insulin secretion, with and without
specific antagonists were carried out to confirm the specific receptor subtypes - DA
D1, DA D2 and NMDA involved in the functional regulation during hyperglycaemic
and hypoglycaemic brain damage. The molecular studies on the brain damage
through dopaminergic and glutamergic receptors will elucidate the therapeutic role in
the corrective measures of the damage to the brain during hypoglycaemia and
hyperglycaemia. This has importance in the management of diabetes and antidiabetic
treatment for better intellectual functioning of the individual.
Description:
Department of
Biotechnology, Cochin University of Science and Technology