Priya Rajan, S; Dr.Mohanan, P V(Cochin University Of Science And Technology, May , 2013)
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Abstract:
The scope of the work was to synthesis few biologically active derivatives
of curcumin. The derivatives were prepared by altering the keto-enol centre of
curcumin by various reagents. This particular reaction centre for preparing
derivative was selected keeping in mind the controversy regarding the major site
responsible for antioxidant mechanism of curcumin. Most of the mechanistic study
done earlier was by varying the constituents in one or both of the phenol ring
present in the curcumin. The alterations at the keto-enol moiety may throw an
insight into the role of the diketo moiety towards the antioxidant mechanism. Since
recently curcumin has been suggested as a chemotherapeutic agent for various
ailments, we also decided to check the DNA intercalating property of the
derivatives synthesised.
Description:
Department of Applied Chemistry
Cochin University of Science and Technology