Bright Singh, I S; Anas, A; Paul, S; Jayaprakash, N S; PhIlip, R(Inter-Research, November 9, 2005)
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Abstract:
Chitosan is a biocompatible and biodegradable natural polymer with established
antimicrobial properties against specific microorganisms. The present study demonstrates its
antibacterial activity against 48 isolates of Vibrio species from prawn larval rearing systems. The
antibacterial activity had a positive correlation with the concentration of chitosan. This work opens
up avenues for using chitosan as a prophylactic biopolymer for protecting prawn larvae from
vibriosis.
Mathew, K T; Robin, Augustine; Ullas, Kalappura G(Wiley InterScience, November , 2008)
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Abstract:
Hydroxyapatite (HAp, Ca10(PO4)6(OH)2) bioceramic and
chitosan (poly [( -1-4) D-glucosamine]) biopolymer show good biocompatibility
in vivo. They have biological origin and show excellent interactions
with microwave. Microwave study of HAp made using different
drying techniques and their composites with chitosan in the ISM band is
presented. Pastes are made using HAp and chitosan with different ratios
of mixing. The dielectric properties of this composites match with that of
human fat, collagen tissues. Some of the compositions exhibit dielectric
property close to that of natural bone. This makes them more
biocompatible and better substitutes for natural bone. Thus composite
bioceramics can be considered as phantom model constituents for
imaging purposes. Their dielectric properties prove that they are
biocompatible.
Jinesh, Mathew; Mahesh, V V; Radhakrishnan, P(International Frequency Sensor Association, August , 2008)
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Abstract:
The design and fabrication of fiber based ammonia sensors employing Bromothymol blue
and Chitosan as sensing elements are presented in this paper. In the presence of ammonia gas the
absorption of Bromothymol blue changes while in the case of Chitosan the refractive index changes
which in turn modulates the intensity of light propagating through a fiber.
Jinesh, Mathew; Thomas, K J; Nampoori, V P N; Radhakrishnan, P(IFSA, 2007)
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Abstract:
A comparative study of two biopolymer based fiber optic humidity sensors is presented in this paper. Sensing elements Agarose and Chitosan swells in the presence of water vapour and undergoes changes in refractive index and modulates the intensity of light propagating through a fiber with Agarose or Chitosan as cladding.
Shilpa, Joy; Dr. Paulose, C S(Cochin University of Science And Technology, July , 2013)
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Abstract:
Nanoparticulate drug delivery systems provide wide opportunities for
solving problems associated with drug stability or disease states and create great
expectations in the area of drug delivery (Bosselmann & Williams, 2012).
Nanotechnology, in a simple way, explains the technology that deals with one
billionth of a meter scale (Ochekpe, et al., 2009). Fewer side effects, poor
bioavailability, absorption at intestine, solubility, specific delivery to site of action
with good pharmacological efficiency, slow release, degradation of drug and
effective therapeutic outcome, are the major challenges faced by most of the drug
delivery systems. To a great extent, biopolymer coated drug delivery systems
coupled with nanotechnology alleviate the major drawbacks of the common
delivery methods. Chitosan, deacetylated chitin, is a copolymer of β-(1, 4) linked
glucosamine (deacetylated unit) and N- acetyl glucosamine (acetylated unit)
(Radhakumary et al., 2005). Chitosan is biodegradable, non-toxic and bio
compatible. Owing to the removal of acetyl moieties that are present in the amine
functional groups of chitin, chitosan is readily soluble in aqueous acidic solution.
The solubilisation occurs through the protonation of amino groups on the C-2
position of D-glucosamine residues whereby polysaccharide is converted into
polycation in acidic media. Chitosan interacts with many active compounds due to
the presence of amine group in it. The presence of this active amine group in
chitosan was exploited for the interaction with the active molecules in the present
study. Nanoparticles of chitosan coupled drugs are utilized for drug delivery in
eye, brain, liver, cancer tissues, treatment of spinal cord injury and infections
(Sharma et al., 2007; Li, et a., 2009; Paolicelli et al., 2009; Cho et al., 2010). To
deliver drugs directly to the intended site of action and to improve
pharmacological efficiency by minimizing undesired side effects elsewhere in the
body and decrease the long-term use of many drugs, polymeric drug delivery
systems can be used (Thatte et al., 2005).
Description:
Department of Biotechnology, Cochin University of Science and Technology