Asha,Abraham; Dr. Paulose, C S(Cochin University of Science And Technology, March 30, 1998)
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Abstract:
I) To study the changes in the content of brain rrrorroamirres in streptozotocirr-irrduced
tliabetes as a lirnction of age and to lirrd the role oliadrenal lrornroncs in diabetic state.
2) To assess the adrenergic receptor function in the brain stem ofstreptozotocin-induced
diabetic rats ofdillerent ages.
3) To study the changes in the basal levels of second messenger cAMP in the brain stenr
ofstreptozotocin-induced diabetic rats as a function of age.
4) To study the changes occurring in the content ofmorroamines and their metabolites in
whole pancreas and isolated pancreatic islets of streptozotocin-diabetic rats as a function
ofage and the effect of adrenal hormones.
5) To study the adrenergic receptors and basal levels of cAMP in isolated pancreatic islets
in young and old streptozotoein-diabetic rats.
6) The in virro study of CAMP content in pancreatic islets of young and old rats and its
ellect on glucose induced insulin secretion.
7) 'lhe in vitro study on the involvement of dopamine and corticosteroids in glucose
induced insulin secretion in pancreatic islets as a function of age.
Description:
Department of
Biotechnology, Cochin University of Science and Technology