The fabrication and analytical applications of two types of potentiometric
sensors for the determination of ketoconazole (KET) are described. The
sensors are based on the use of KET-molybdophosphoric acid (MPA) ion pair
as electroactive material. The fabricated sensors include both polymer membrane
and carbon paste electrodes. Both sensors showed a linear, stable and near
Nernstian slope of 57.8mV=decade and 55.2mV=decade for PVC membrane
and carbon paste sensors respectively over a relatively wide range of KET concentration
(1×10-2-5×10-5 and 1×10-2-1×10-6). The sensors showed a fast
response time of <30 sec and <45 sec. A useful pH range of 3–6 was obtained
for both types of sensors. A detection limit of 2.96 10 5M was obtained for
PVC membrane sensor and 6.91 10 6M was obtained for carbon paste sensor.
The proposed sensors proved to have a good selectivity for KET with respect to a
large number of ions. The proposed sensors were successfully applied for the
determination of KET in pharmaceutical formulations. The results obtained
are in good agreement with the values obtained by the standard method.
Girish Kumar,K; Pearl, Augustine; Sareena, John(Springer, August 29, 2009)
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Abstract:
The fabrication and electrochemical response
characteristics of two novel potentiometric sensors for the
selective determination of domperidone (DOM) are described.
The two fabricated sensors incorporate DOM–PTA
(phosphotungstic acid) ion pair as the electroactive material.
The sensors include a PVC membrane sensor and a carbon
paste sensor. The sensors showed a linear, stable, and near
Nernstian slope of 56.5 and 57.8 mV/decade for PVC
membrane and carbon paste sensors, respectively over a
relatively wide range of DOM concentration (1.0 9
10-1–1.0 9 10-5 and 1.0 9 10-1–3.55 9 10-6 M). The
response time of DOM–PTA membrane sensor was less than
25 s and that in the case of carbon paste sensor was less than
20 s.Auseful pH range of 4–6 was obtained for both types of
sensors. A detection limit of 7.36 9 10-5 M was obtained
for PVC membrane sensor and 1.0 9 10-6 M was obtained
for carbon paste sensor. The proposed sensors showed very
good selectivity toDOMin the presence of a large number of
other interfering ions. The analytical application of the
developed sensors in the determination of the drug in pharmaceutical
formulations such as tablets was investigated.
The results obtained are in good agreement with the values
obtained by the standard method. The sensors were also
applied for the determination ofDOMin real samples such as
urine by the standard addition method.
Description:
J Appl Electrochem (2010) 40:65–71
DOI 10.1007/s10800-009-9975-2