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Please use this identifier to cite or link to this item: http://purl.org/purl/647

Title: Dopaminergic Regulation of Glucose-induced Insulin Secretion through Dopamine D2 Receptors in the Pancreatic Islets In Vitro
Authors: Eswar Shankar,P N
Santhosh,K T
Paulose,C S
Keywords: Dopamine
Norepinephrine
Dopamine D2 receptors
Insulin secretion
Diabetes
pancreatic islets
Neurotransmitters
Issue Date: Mar-2006
Publisher: Department of Biotechnology
Abstract: The stimulatory effect of dopamine through dopamine 1)2 receptor on glucose - induced insulin secretion was studied in the pancreatic islets in nitro. I)oparnilie signifieanlly stimula(ed insulin secretion at a concentration of 10 a N1 in the presence of high,glucose ( 20 nii1 ). ' fhe higher concentrations of dopamine (111 -1() 4) inhibited glucose- induced insulin secretion in the presence of both 4 mM1 and 20 m M glucose. Stimulatory and inhibitory effect of dopamine on glucose - induced insulin secretion was reverted by the addition of dopamine 1)2 receptor antagonists such as butaclamol and sulpiride . Norepinephrine (NE) at 111 4 11 concentration inhibited the dopamine uptake as well as its stimulatory effect at 11) - 8 IN1 concentration on glucose induced insulin secretion. Our results suggest that dopamine exerts a differential effect on glucose -induced insulin secretion through dopamine D2 receptor and it is essential for the regulation of glucose-induced insulin secretion by pancreatic islets.
URI: http://dyuthi.cusat.ac.in/purl/647
Appears in Collections:Dr.C S Paulose

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