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Please use this identifier to cite or link to this item: http://purl.org/purl/593

Title: Pineal indoleamine metabolism in pyridoxine-deficient rats
Authors: Viswanathan,M
Siow,Y L
Paulose,C S
Dakshinamurti,K
Keywords: Pineal gland
Pyridoxine deficiency
Aromatic amino acid decarboxylase
Serotonin
Melatonin
Issue Date: 24-May-1988
Publisher: Department of Biotechnology
Abstract: Pvridoxine deficiency causes physiologically significant decrease in brain serotonin (5-HT) due to decreased decarboxylation of 5- hvdroxvtrvptophan (5-HTP). We have examined the effect of pyridoxine deficiency on indoleamine metabolism in the pineal gland, a tissue with high indoleamine turnover. Adult male Sprague-Dawley rats were fed either a pyridoxine-supplemented or pyridoxinedeficient diet for 8 weeks. Pyridoxine deficiency did not alter the pattern of circadian rhythm of pineal 5-HT. 5-hvdroxvindoleacetic acid (5-HIAA), V-acetvlserotonin (NAS). and melatonin. However the levels of these compounds were significantly lower in the pineal glands of pyridoxine-deficient animals. Pineal 5-HTP levels were consistently higher in the pyridoxine-deficient animals and a conspicuous increase was noticed at 22.00 h. Increase in pineal NAS and melatonin levels caused by isoproterenol (5 mg kg at 17.00 h) were significantly lower (P < 0.05) in the pyridoxine-deficient animals. Treatment of pyridoxine-deficient rats with pvridoxine restored the levels of pineal 5-HT, 5-HIAA. NAS. and melatonin to values seen in pyridoxine-supplemented control animals. These results suggest that 5-HT availability could be an important factor in the regulation of the synthesis of pineal NAS and melatonin.
URI: http://dyuthi.cusat.ac.in/purl/593
Appears in Collections:Dr.C S Paulose

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