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http://purl.org/purl/584
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Title: | Effect of leaf extract of Aegle marmelose in diabetic rats |
Authors: | Ponnachan,P T C Paulose,C S Panikkar, K R |
Keywords: | Aegle marmelose diabetes mellitus Plant extracts Swertia chirayita hypoglycaemic activity |
Issue Date: | Apr-1993 |
Publisher: | Department of Biotechnology |
Abstract: | Alloxan induced animal model was used to evaluate the potential antidiabetic effect of A . marmelose leaf
extract. The diabetic animals were given insulin injection and another group A . marmelose leaf extract orally.
It maintained the weight of the animals near to the control rats but a significant decrease in weight was noted it
diabetic animals without any treatment . The blood elucose level in 'treated animals were near to that of control
ones. Also a significantly increased glucose tolerance was observed in animals orally given the leaf extract
prior to the experiment . A significant decrease in liver glycogen ( 1.24 -.07 s!/ 100 g of wet tissue) was observed
in diabetic rats which was brought to almost the normal level (I.84- . 14 g; 100 g) with Icaf extract treatment.
Blood urea and serum cholesterol increased ( 62.66 - 3.50 and 192.67± 13.64 mg' dl) significantly in alloxxan
diabetic rats . The leaf extract treatment decreased the blood urea and serum . cholesterol (37.83 - 3.97 and
99?0±8.43 mg/dl ) to that of control ones . A similar effect was seen with insulin treatment . The results
indicate that the active principle in .4. marmelose leaf extract has similar hypoglycaemic activity to insulin
treatment. |
URI: | http://dyuthi.cusat.ac.in/purl/584 |
Appears in Collections: | Dr.C S Paulose
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