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Please use this identifier to cite or link to this item: http://purl.org/purl/4258

Title: Protease inhibitor from Moringa oleifera with potential for use as therapeutic drug and as seafood preservative
Authors: Chandrasekaran, M
Bijina, B
Sreeja, Chellappan
Jissa, Krishna G
Soorej, Basheer M
Elyas, K K
Ali, Bahkali H
Keywords: Moringa oleifera
Protease inhibitor
Seafood preservative
Therapeutic proteases
Issue Date: 18-Apr-2011
Publisher: Elsevier
Abstract: Protease inhibitors are well known to have several applications in medicine and biotechnology. Several plant sources are known to return potential protease inhibitors. In this study plants belonging to different families of Leguminosae, Malvaceae, Rutaceae, Graminae and Moringaceae were screened for the protease inhibitor. Among them Moringa oleifera, belonging to the family Moringaceae, recorded high level of protease inhibitor activity after ammonium sulfate fractionation. M. oleifera, which grows throughout most of the tropics and having several industrial and medicinal uses, was selected as a source of protease inhibitor since so far no reports were made on isolation of the protease inhibitor. Among the different parts of M. oleifera tested, the crude extract isolated from the mature leaves and seeds showed the highest level of inhibition against trypsin. Among the various extraction media evaluated, the crude extract prepared in phosphate buffer showed maximum recovery of the protease inhibitor. The protease inhibitor recorded high inhibitory activity toward the serine proteases thrombin, elastase, chymotrypsin and the cysteine
Description: Saudi journal of biological sciences(2011) 18,273-281
URI: http://dyuthi.cusat.ac.in/purl/4258
Appears in Collections:Dr. M Chandrasekharan

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