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Please use this identifier to cite or link to this item: http://purl.org/purl/4078

Title: Molecular Characterisation and Phylogenetic Analysis of a Novel Isoform of Hepatic Antimicrobial Peptide, Hepcidin (Zc-hepc1), from the Coral Fish Moorish idol, Zanclus cornutus (Linnaeus,1758)
Authors: Bright Singh, I S
Rosamma, Philip
Chaithanya, E R
Anil Kumar, P R
Sherine, Sonia Cubelio
Naveen, Sathyan
Keywords: Antimicrobial peptide
Moorish idol
Zanclus cornutus
Hepcidin
Coral fish
Innate immunity
Issue Date: 23-May-2013
Publisher: Springer
Abstract: Hepcidin is a family of short cysteine-rich antimicrobial peptides (AMPs) participating in various physiological functions with inevitable role in host immune responses. Present study deals with identification and characterisation of a novel hepcidin isoform from coral fish Zanclus cornutus. The 81 amino acid (aa) preprohepcidin obtained from Z. cornutus consists of a hydrophobic aa rich 22 mer signal peptide, a highly variable proregion of 35 aa and a bioactive mature peptide with 8 conserved cysteine residues which contribute to the disulphide back bone. The mature hepcidin, Zc-hepc1 has a theoretical isoelectric point of 7.46, a predicted molecular weight of 2.43 kDa and a net positive charge of ?1. Phylogenetic analysis grouped Z. cornutus hepcidin with HAMP2 group hepcidins confirming the divergent evolution of hepcidin-like peptide in fishes. Zc-hepc1 can attain a b-hairpin-like structure with two antiparallel b-sheets. This is the first report of an AMP from the coral fish Z. cornutus.
Description: Probiotics & Antimicro. Prot. (2013) 5:187–194 DOI 10.1007/s12602-013-9139-x
URI: http://dyuthi.cusat.ac.in/purl/4078
Appears in Collections:Bright Singh I S

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