DSpace About DSpace Software
 

Dyuthi @ CUSAT >
e-SCHOLARSHIP >
Environmental Studies >
Faculty >
Bright Singh I S >

Please use this identifier to cite or link to this item: http://purl.org/purl/4069

Title: Characterization of Histone H2A Derived Antimicrobial Peptides, Harriottins, from Sicklefin Chimaera Neoharriotta pinnata (Schnakenbeck, 1931) and Its Evolutionary Divergence with respect to CO1 and Histone H2A
Authors: Bright Singh, I S
Rosamma, Philip
Naveen, Sathyan
Chaithanya, E R
Anil Kumar, P R
Sanjeevan, V N
Issue Date: 8-May-2013
Publisher: Hindawi Publishing Corporation
Abstract: Antimicrobial peptides (AMPs) are humoral innate immune components of fishes that provide protection against pathogenic infections. Histone derived antimicrobial peptides are reported to actively participate in the immune defenses of fishes. Present study deals with identification of putative antimicrobial sequences from the histone H2A of sicklefin chimaera, Neoharriotta pinnata. A 52 amino acid residue termed Harriottin-1, a 40 amino acid Harriottin-2, and a 21 mer Harriottin-3 were identified to possess antimicrobial sequence motif. Physicochemical properties andmolecular structure ofHarriottins are in agreement with the characteristic features of antimicrobial peptides, indicating its potential role in innate immunity of sicklefin chimaera. The histone H2A sequence of sicklefin chimera was found to differ from previously reported histone H2A sequences. Phylogenetic analysis based on histone H2A and cytochrome oxidase subunit-1 (CO1) gene revealed N. pinnata to occupy an intermediate position with respect to invertebrates and vertebrates
Description: ISRN Molecular Biology Volume 2013, Article ID 930216, 10 pages
URI: http://dyuthi.cusat.ac.in/purl/4069
Appears in Collections:Bright Singh I S

Files in This Item:

File Description SizeFormat
Characterization of Histone H2A Derived Antimicrobial Peptides, Harriottins, from Sicklefin Chimaera Neoharriotta pinnata (Schnakenbeck, 1931) and Its Evolutionary Divergencewith respect to CO1.pdfpdf6.16 MBAdobe PDFView/Open
View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback