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Please use this identifier to cite or link to this item: http://purl.org/purl/3260

Title: “Development of lymphoid cell culture system from Penaeus monodon and molecular approaches for its transformation
Authors: Jayesh, P
Dr.Bright Singh,I S
Keywords: Crustacean cell culture
Cell culture from shrimp
in vitro cell culture
shrimp cell culture medium
lymphoid cell culture
Issue Date: Sep-2012
Publisher: Cochin University of Science and Technology
Abstract: Unveiling the molecular and regulatory mechanisms that prevent in vitro transformation in shrimp remains elusive in the development of continuous cell lines, with an arduous history of over 25 years (Jayesh et al., 2012). Despite presenting challenges to researchers in developing a cell line, the billion dollar aquaculture industry is under viral threat. In addition, the regulatory mechanisms that prevent in vitro transformation and carcinoma in shrimps might provide new leads for the development of anti-ageing and anti-cancer interventions in human (Vogt, 2011) and in higher vertebrates. This highlights the importance of developing shrimp cell lines, to bring out effective prophylactics against shrimp viruses and for understanding the mechanism that induce cancer and ageing in human.. Advances in molecular biology and various gene transfer technologies for immortalization of cells have resulted in the development of hundreds of cell lines from insects and mammals, but yet not a single cell line has been developed from shrimp and other marine invertebrates. With this backdrop, the research described in this thesis attempted to develop molecular tools for induced in vitro transformation in lymphoid cells from Penaeus monodon and for the development of continuous cell lines using conventional and novel technologies to address the problems at cellular and molecular level.
Description: National Centre for Aquatic Animal Health, School of Environmental Studies, Cochin University of Science and Technology
URI: http://dyuthi.cusat.ac.in/purl/3260
Appears in Collections:Faculty of Environmental Studies

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