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Please use this identifier to cite or link to this item: http://purl.org/purl/2806

Title: Dopamine D1 and D2 Receptor Functional Regulation:Glutamate Receptor Gene Expression in the Brain of Hypoglycaemic and Hyperglycaemic Rats
Authors: Remya, Robinson
Dr. Paulose, C S
Keywords: Dopamine
Dopamine DI receptor
Glutamate
Hypoglycaemia
Diabetes
Brain neurotransmitters
Insulin secretion
Biotechnology
Issue Date: Apr-2007
Publisher: Cochin University of Science and Technology
Abstract: In the present study a detailed investigation on the alterations of dopamine and its receptors in the brain regions of streptozotocin induced diabetic and insulin induced hypoglycaemic rats were carried out. Glutamate receptor, NMDARI gene expression in the hypoglycaemic and hyperglycaemic brain was also studied. EEG recording in hypoglycaemic and hyperglycaemic will be carried out to measure brain activity. in vitro studies on glucose uptake and insulin secretion, with and without specific antagonists were carried out to confirm the specific receptor subtypes - DA D1, DA D2 and NMDA involved in the functional regulation during hyperglycaemic and hypoglycaemic brain damage. The molecular studies on the brain damage through dopaminergic and glutamergic receptors will elucidate the therapeutic role in the corrective measures of the damage to the brain during hypoglycaemia and hyperglycaemia. This has importance in the management of diabetes and antidiabetic treatment for better intellectual functioning of the individual.
Description: Department of Biotechnology, Cochin University of Science and Technology
URI: http://dyuthi.cusat.ac.in/purl/2806
Appears in Collections:Faculty of Sciences

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