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Please use this identifier to cite or link to this item: http://purl.org/purl/2346

Title: Muscarinic M1, M3, Nicotinic,GABAA and GABAB Receptor Subtypes Gene Expression in Insulin Induced Hypoglycemic Rat Brain Regions: Functional Regulation through Phospholipase C and CREB Protein
Authors: Sherin, Antony
Dr. Paulose, C S
Keywords: Muscarinic M1 receptor
Muscarinic M3 receptor
Nicotinic Receptors
GABA Receptors
GABAB Receptors
Phospholipase C
CREB Protein
Issue Date: May-2010
Publisher: Cochin University of Science & Technology
Abstract: In the present study, a detailed investigation on the alterations of muscarinic M1, M3, α7 nicotinic acetylcholine receptor (α7 nAchR), GABA receptors and its subtypes; GABAAα1 and GABAB in the brain regions of streptozotocin induced diabetic and insulin induced hypoglycemic rats were carried out. Gene expression of acetylcholine esterase (AChE), choline acetyltransferase (ChAT), GAD, GLUT3, Insulin receptor, superoxide dismutase (SOD), Bax protein, Phospholipase C and CREB in hypoglycemic and hyperglycemic rat brain were studied. Muscarinic M1, M3 receptors, AChE, ChAT, GABAAα1, GABAB, GAD, Insulin receptor, SOD, Bax protein and Phospholipase C expression in pancreas was also carried out. The molecular studies on the CNS and PNS damage will elucidate the therapeutic role in the corrective measures of the damage to the brain during hypoglycemia and hyperglycemia.
Description: Department of Biotechnology,Cochin University of Science and Technology
URI: http://dyuthi.cusat.ac.in/purl/2346
Appears in Collections:Faculty of Sciences

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