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Please use this identifier to cite or link to this item: http://purl.org/purl/1991

Title: Electrochemical Reduction and Voltammetric Determination of Metronidazole Benzoate at Modified Carbon Paste Electrode
Authors: Girish Kumar,K
Joseph, Renjini
Science
Keywords: Carbon paste electrode
cyclic voltammetry
electrochemical reduction
metalloporphyrin
metronidazole benzoate
Issue Date: 1-Jun-2009
Publisher: Taylor & Francis
Abstract: A metalloporphyrin incorporated carbon paste sensor has been developed for the determination of metronidazole benzoate (MTZB). Zn(II) complex of 5,10,15,20-tetrakis (3-methoxy-4-hydroxy phenyl) porphyrin (TMHPP) was used as the active material. The MTZB gave a well-defined reduction peak at - 0.713V in 0.1 mol l -1 phosphate buffer solution of pH around 7. Compared with bare carbon paste electrode (CPE), the TMHPP Zn(II) modified electrode significantly enhanced the reduction peak current of MTZB as well as lowered its reduction potential. Under optimum conditions the reduction peak current was proportional to MTZB concentration over the range 1×10-3 mol1-1 to 1×10-5mol1-1. The detection limit was found to be 4.36×10-6mol1-1 . This sensor has been successfully applied for the determination of MTZB in pharmaceutical formulations and urine samples.
URI: http://dyuthi.cusat.ac.in/xmlui/purl/1991
ISSN: 0003-2719
Appears in Collections:Dr. K Girish Kumar

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