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Please use this identifier to cite or link to this item: http://purl.org/purl/1929

Title: Spectrophotometric Methods for the Determination of Cafotaxime Sodium In Dosage Forms
Authors: Girish Kumar,K
Devala Rao, G
Chowdary, K P R
Keywords: Cefotaxime Sodium
Ultra Violet Spectrophotometric method
Issue Date: 7-Feb-2001
Publisher: Indian Journal Of Pharmaceutical Sciences
Citation: Department of Applied Chemistry, Cochin University of Science and Technology
Abstract: Two simple and sensitive spectrophotometric methods(A and B) in the visible region have been developed for the determination of cefotaxime sodium (DFTS) in bulk and in dosage forms. Method A is based on the reaction of CFTS with nitrous acid under alkaline conditions to form a stable violet colored chromogen with absorption maximum of 560 nm and method B is based on the reaction of CFTS with1,10-phenanthroline and ferric chloride to form a red colored chromogen with the absorption maximum of 520 mm.The color obeyed Beer’s law in the concentration range of 100-500 µg/ml for method A and 1.6-16 µg/ml for method B, respectively.When pharmaceutical preparations containing CFTS were analysed, the results obtained by the proposed methods are in good agreement with the labeled amounts and are comparable with the results obtained using a UV spectrophotometric method.
URI: http://dyuthi.cusat.ac.in/xmlui/purl/1929
Appears in Collections:Dr. K Girish Kumar

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