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Abstract:
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purpose of this study was to investigate the
role of brain al-adrenergic receptor binding in the rat model
of pancreatic regeneration using 60-70% pancre:dectorny.
The a, -adrenergic receptors kinetics was studied in the
cerebral cor:cx and brain stem of sham operated . 72 It pan-
crea(ectoinised and 7 days pancreatectomised rats. Scar
chard analysis with I `I I lprazocin in cerebral cartes and brain
stein showed a significant decrease (/' < 0.01). (P < 0.05)
in maximal binding ( 1),,,,,) with it significant decrease
(P < 0.001 ), ( P < 0.01) in the K,,in 72 It pancreatecto-
raised rats compared with sham , respectively . Competition
analysis in cerebral cortex and brain stem showed it shift in
affinity during pancreatic regeneration . The sympathetic
activity was decreased as indicated by the significantly de-
increased norepinephrine level in the plasma (P < 0.001),
cerebral cortex (P < 0.01) and brain stem (P < 0.001) of
72 h pancreatectomised rats compared to sham . Thus, from
our results it is suggested that the central a, -adrenergic
receptors have a functional role in the pancreatic regenera-
Lion mediated through the sympathetic pathway. |