| dc.contributor.author |
Mohanan,Valiyaveettil |
|
| dc.contributor.author |
Finla, Chathu |
|
| dc.contributor.author |
Paulose, Cheramadathikudyil S |
|
| dc.date.accessioned |
2008-07-30T06:48:19Z |
|
| dc.date.available |
2008-07-30T06:48:19Z |
|
| dc.date.issued |
2004-12-01 |
|
| dc.identifier.uri |
http://dyuthi.cusat.ac.in/purl/527 |
|
| dc.description.abstract |
The purpose of this study was to investigate the role of central 5-HT2C receptor binding in rat model of pancreatic regeneration
using 60-70% pancreatectomy. The 5-HT and 5-HT2c receptor kinetics were studied in cerebral cortex and brain stem of sham
operated, 72 h pancreatectomised and 7 days pancreatectomised rats. Scatchard analysis with [3H] mesulergine in cerebral
cortex showed a significant decrease (p < 0.05) in maximal binding (B^,ax) without any change in Kd in 72 h pancreatectomised
rats compared with sham. The decreased Bmax reversed to sham level by 7 days after pancreatectomy. In brain stem , Scatchard
analysis showed a significant decrease (p < 0.01) in Bax with a significant increase (p < 0.01) in Kd. Competition analysis
in brain stem showed a shift in affinity towards a low affinity. These parameters were reversed to sham level by 7 days after
pancreatectomy. Thus the results suggest that 5-HT through the 5-HT2C receptor in the brain has a functional regulatory role in
the pancreatic regeneration. (Mol Cell Biochem 272: 165-170, 2005) |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
Department of Bio Technology |
en_US |
| dc.subject |
cerebral cortex |
en_US |
| dc.subject |
brain stem |
en_US |
| dc.subject |
5-HT2C receptor |
en_US |
| dc.subject |
pancreas |
en_US |
| dc.subject |
regeneration |
en_US |
| dc.title |
Decreased 5-HT2C receptor binding in the cerebral cortex and brain stem during pancreatic regeneration in rats |
en_US |
| dc.type |
Working Paper |
en_US |