| dc.description.abstract |
Pyridoxal phosphate (PLP) is the coenzyme of various decarboxylases involved in the
formation of monoamine urotransmitters such as y-aminobulyric acid (GAE3A),
serotonin (5-HT) and dopamine. 1-lowever; in the pyridoxine-deficient rats GABA and
5-HT are decreased in various brain areas including the hypothalamus, with no change
in the catecholamine levels. Serotonin and GABA are known to be involved in blood
pressure control mechanisms. In this study adult Sprague-Dawley rats placed on a
pyridoxine-deficient diet for 8 weeks showed significant hypertension compared with
pyridoxine-supplemented controls. This was associated with a general sympathetic
stimulation. Treatment of deficient rats with a single dose of pyridoxine (10 mg/kg body
weight) reversed the blood pressure to normal levels within 24 h, with concomitant
restoration of hypothalamic 5-HT and GABA, as well as the return of plasma
norepinephrine to nornr;l levels. The results indicate that there is a cause-and-effect
relationship between pyridoxine deficiency and hypertension. |
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