Effect of leaf extract of Aegle marmelose in diabetic rats

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Effect of leaf extract of Aegle marmelose in diabetic rats

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dc.contributor.author Ponnachan, P T C
dc.contributor.author Paulose, C S
dc.contributor.author Panikkar, K R
dc.date.accessioned 2008-08-04T06:41:50Z
dc.date.available 2008-08-04T06:41:50Z
dc.date.issued 1993-04
dc.identifier.uri http://dyuthi.cusat.ac.in/purl/584
dc.description.abstract Alloxan induced animal model was used to evaluate the potential antidiabetic effect of A . marmelose leaf extract. The diabetic animals were given insulin injection and another group A . marmelose leaf extract orally. It maintained the weight of the animals near to the control rats but a significant decrease in weight was noted it diabetic animals without any treatment . The blood elucose level in 'treated animals were near to that of control ones. Also a significantly increased glucose tolerance was observed in animals orally given the leaf extract prior to the experiment . A significant decrease in liver glycogen ( 1.24 -.07 s!/ 100 g of wet tissue) was observed in diabetic rats which was brought to almost the normal level (I.84- . 14 g; 100 g) with Icaf extract treatment. Blood urea and serum cholesterol increased ( 62.66 - 3.50 and 192.67± 13.64 mg' dl) significantly in alloxxan diabetic rats . The leaf extract treatment decreased the blood urea and serum . cholesterol (37.83 - 3.97 and 99?0±8.43 mg/dl ) to that of control ones . A similar effect was seen with insulin treatment . The results indicate that the active principle in .4. marmelose leaf extract has similar hypoglycaemic activity to insulin treatment. en_US
dc.language.iso en en_US
dc.publisher Department of Biotechnology en_US
dc.subject Aegle marmelose en_US
dc.subject diabetes mellitus en_US
dc.subject Plant extracts en_US
dc.subject Swertia chirayita en_US
dc.subject hypoglycaemic activity en_US
dc.title Effect of leaf extract of Aegle marmelose in diabetic rats en_US
dc.type Working Paper en_US


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