Decreased 5-HT2C receptor binding in the cerebral cortex and brain stem during pancreatic regeneration in rats

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Decreased 5-HT2C receptor binding in the cerebral cortex and brain stem during pancreatic regeneration in rats

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dc.contributor.author Mohanan, Valiya Veettil
dc.contributor.author Finla, Chathu
dc.contributor.author Paulose, Cheramadathikudyil S
dc.date.accessioned 2008-07-30T06:48:19Z
dc.date.available 2008-07-30T06:48:19Z
dc.date.issued 2004-12-01
dc.identifier.uri http://dyuthi.cusat.ac.in/purl/527
dc.description.abstract The purpose of this study was to investigate the role of central 5-HT2C receptor binding in rat model of pancreatic regeneration using 60-70% pancreatectomy. The 5-HT and 5-HT2c receptor kinetics were studied in cerebral cortex and brain stem of sham operated, 72 h pancreatectomised and 7 days pancreatectomised rats. Scatchard analysis with [3H] mesulergine in cerebral cortex showed a significant decrease (p < 0.05) in maximal binding (B^,ax) without any change in Kd in 72 h pancreatectomised rats compared with sham. The decreased Bmax reversed to sham level by 7 days after pancreatectomy. In brain stem , Scatchard analysis showed a significant decrease (p < 0.01) in Bax with a significant increase (p < 0.01) in Kd. Competition analysis in brain stem showed a shift in affinity towards a low affinity. These parameters were reversed to sham level by 7 days after pancreatectomy. Thus the results suggest that 5-HT through the 5-HT2C receptor in the brain has a functional regulatory role in the pancreatic regeneration. (Mol Cell Biochem 272: 165-170, 2005) en_US
dc.language.iso en en_US
dc.publisher Department of Bio Technology en_US
dc.subject cerebral cortex en_US
dc.subject brain stem en_US
dc.subject 5-HT2C receptor en_US
dc.subject pancreas en_US
dc.subject regeneration en_US
dc.title Decreased 5-HT2C receptor binding in the cerebral cortex and brain stem during pancreatic regeneration in rats en_US
dc.type Working Paper en_US


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