Ani Das, V; Remya, Robinson; Paulose,C S(Department of Bio Technology, January 23, 2006)
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Abstract:
Adrenergic stimulation has an inyortant role in the pancreatic It-cell proliferation and insulin secretion. In the present study. we
have investigaled how sympathetic system mgulales the panrrealic n I rnerui nr ht an:ilyiing I'pinephi inn 1111 ), Norepinephrinc
(NE) and /1-adrenergic receptor changes in the brain as (%eli is in the I swirls. Fill and NII showed a significant decrease in
the brain regions, pancreas and plasma :rt 72Ius iller partial prurcrealectonty. We observed an increase in the circulating insulin
levels at 72 hrs. Scatchard analysis using I CHI propranolol showed a significant increase in the number of loth the low affinity
and high affinity t-adrenergic receplors in cerebral cortex and hypothalamus of partially pancreatectornised rats during peak
DNA synthesis. The affinity of the receptors decrea,ed significantly in the low and high affinity receptors of cerebral cortex
and the high affinity hypothalamic receptors. In file brain stein, low affinity receptors were increased significantly during
regeneration whereas there was no change in the high affinity receptors. The pancreatic ff-adrenergic receptors were also up
regulated at 72 firs after partial panerealectony. In vitro studies showed that /i-adrenergic receptors are positive regulators of
islet cell proliferation and insulin secretion. Thus our results suggest that the t-adrenergic receptors are functionally enhanced
during pancreatic regeneration, which in turn increases pancreatic ft-cell proliferation an(hilisulin secretion in wean hug rats.