Eswar Shankar,P N; Santhosh,K T; Paulose,C S(Department of Biotechnology, March , 2006)
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Abstract:
The stimulatory effect of dopamine through dopamine 1)2
receptor on glucose - induced insulin secretion was studied in the
pancreatic islets in nitro. I)oparnilie signifieanlly stimula(ed insulin
secretion at a concentration of 10 a N1 in the presence of
high,glucose ( 20 nii1 ). ' fhe higher concentrations of dopamine
(111 -1() 4) inhibited glucose- induced insulin secretion in the
presence of both 4 mM1 and 20 m M glucose. Stimulatory and
inhibitory effect of dopamine on glucose - induced insulin secretion
was reverted by the addition of dopamine 1)2 receptor antagonists
such as butaclamol and sulpiride . Norepinephrine (NE) at 111 4 11
concentration inhibited the dopamine uptake as well as its
stimulatory effect at 11) - 8 IN1 concentration on glucose induced
insulin secretion. Our results suggest that dopamine exerts a
differential effect on glucose -induced insulin secretion through
dopamine D2 receptor and it is essential for the regulation of
glucose-induced insulin secretion by pancreatic islets.
Paulose,C S; Amee,Krishnakumar; Anu, Joseph(Department of Biotechnology, 2007)
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Abstract:
Neuroscience is the study of'tbe ne rvous system , including the i - ; . in, spinal
cord and peripheral nerves . Neurons are the basic cells of the brain and
nervous system which exerts its functional role through various
neurotransmitters and receptor systems . The activity of a nen ren depends
on the balance between the number of excitatory and inhibito r y processes
affecting it, both processes occurring individually and sin ,tlte-' ,ieously. The
functional bal,ince of different neurotransmitters such as Acct >>lcholine
(Ach), Dopamine (DA), Serotonin (5-1-17), Nor epinepbri,te (N.1 j,
Epinephrine (LPI), Glutamate and Gamma amino butyric acid (GA BA)
regulates the growth , division and other vital functions ofa normal cell /
organisin (Sudha, 1 998). The micro-environ ; nertt of the cell is controlled
/ the macro-environment that surrounds the individual. Any change in
the cell environment causes imbalance in cell homeostasis and f,ntction.
Pollution is a significant cause of imbalance caused iii the inacYcenvironment.
Interaction with polluted environments can have an adverse
impact on the health of humans. The alarming rise in enviromilmieil
cont.iniin :rtion has been linked to rises in levels of pesticides, ndltstr al
effluents, domestic Waste, car exhausts and other anthropogenic activities.
Persistent exposures to contaminant cause a negative imp,-, on brain
health and development . Pollution also causes a change in the
neurotransmitters and their receptor function leading to earl.;' recurrence
of neurodcge,terative disorders such as flypoxia , Alzbeimers's and
Huntington 's disease early in life.
Paulose,C S; Amee,Krishnakumar; Anu, Joseph(Department of Biotechnology, October 25, 2006)
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Abstract:
The recent developments in neurobiology have rendered new prominence
and potential to study about the structure and function of brain and related disorders.
Human behaviour is the net result of neural control of the communication between
brain cells. Neurotransmitters are chemicals that are used to relay, amplify and
modulate electrical signals between neurons and/or another cell. It mediates rapid
intercellular communication through the nervous system by interacting with cell
surface receptors. These receptors often trigger second messenger signaling pathways
that regulate the activity of ion channels. The functional balance of different
neurotransmitters such as Acetylcholine (Ach), Dopamine (DA), Serotonin (5-HT),
Norepinephrine (NE), Epinephrine (EPI), Glutamate and Gamma amino butyric acid
(GABA) regulates the growth, division and other vital functions of a normal cell /
organism (Sudha, 1998). Any change in neurotransmitters' functional balance will
result in the failure of cell function and may lead to the occurrence of diseases.
Abnormalities in the production or functioning of neurotransmitters have been
implicated in a number of neurological disorders like Schizophrenia, Alzheimer's,
Epilepsy, Depression and Parkinson's disease. Changes in central and peripheral
neuronal signaling system is also noted in diabetes, cancer, cell proliferation,
alcoholism and aging. Elucidation of neurotransmitters receptor interaction pathways
and gene expression regulation by second messengers and transcriptional factors
in health and disease conditions can lead to new small molecules for development
of therapeutic agents to improve neurological disease conditions. Increased
awareness of the global effects of neurological disorders should help health care
planners and the neurological community set appropriate priorities in research,
prevention, and management of these diseases.