Dakshinamurti,K; Paulose,C S; Viswanathan,M; Siow,Y L(Department of Biotechnology, 1988)
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Abstract:
Veuruenducrim lri v j p .rim,
deficienc:v. NEUROSCI BIOBEHAV REV 12(3/4) 189-193. 1988.- Dihydroxyphenylalanine decarboxvlase and
5-hydroxytryptophan decarboxvlase respectively have high and low affinities for pyridoxal phosphate. In the pyridoxinedeficient
animal. hypothalamic serotonin content is significantly reduced without any change in catecholamine levels.
Hypothalamic neurotransmitters affect the hvpothalamo-pituitary-end organ axes. Specifically, the decrease in hypothalamic
serotonin in the pyridoxine-deficient rat results in tertiary hypothyroidism. In addition. pineal function is affected in
deficient animals due to decreased synthesis of melatonin.