Jackson,James; Pius S,Padayatti; Thomas,Paul; Paulose,C S(Department of Biotechnology, December 13, 1996)
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Abstract:
In the present study we assessed plasma and platelet
monoamine content using high performance liquid
chromatography (HPLC). The study included 22 subjects
consisting of 12 freshly-detected male diabetic
patients and 10 age and sex-matched healthy controls.
The same parameters were measured in streptozotocin
-induced diabetic rat models consisting of
controls , diabetic and insulin - treated diabetic rats.
The platelet counts were significantly reduced
(P < 0.05) in rat models as well as human diabetic
samples. The plasma norepinephrine (NE) and epinephrine
(EPI) concentrations were significantly increased
(P < 0.05). The platelet showed a significant
increase (P < 0.01) in NE, EPI and serotonin content.
Increase in the plasma and platelet content of neurotransmitters
may be due to increased sympathetic
function, which is an adaptation for the decreased
platelet count observed in our study . The results indicate
that changes in the neurotransmitter content
of the platelet may be a good index to assess the neurotransmitter
status in pathological condition such as
diabetes mellitus.