Down-regulation of cerebellar 5-HT2C receptors in pilocarpine-induced epilepsy in rats: Therapeutic role of Bacopa monnieri extract

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Down-regulation of cerebellar 5-HT2C receptors in pilocarpine-induced epilepsy in rats: Therapeutic role of Bacopa monnieri extract

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dc.contributor.author Paulose,C S
dc.contributor.author Amee,Krishnakumar
dc.contributor.author Pretty Mary,Abraham
dc.contributor.author Jes,Paul
dc.date.accessioned 2010-03-30T07:04:52Z
dc.date.available 2010-03-30T07:04:52Z
dc.date.issued 2009
dc.identifier.citation Cochin University of Science and Technology en_US
dc.identifier.other Journal of the Neurological Sciences 284 (2009) 124–128
dc.identifier.uri http://dyuthi.cusat.ac.in/purl/1621
dc.description.abstract Epilepsy is a syndrome of episodic brain dysfunction characterized by recurrent unpredictable, spontaneous seizures. Cerebellar dysfunction is a recognized complication of temporal lobe epilepsy and it is associated with seizure generation, motor deficits and memory impairment. Serotonin is known to exert a modulatory action on cerebellar function through 5HT2C receptors. 5-HT2C receptors are novel targets for developing anticonvulsant drugs. In the present study, we investigated the changes in the 5-HT2C receptors binding and gene expression in the cerebellum of control, epileptic and Bacopa monnieri treated epileptic rats. There was a significant down regulation of the 5-HT content (pb0.001), 5-HT2C gene expression (pb0.001) and 5-HT2C receptor binding (pb0.001) with an increased affinity (pb0.001). Carbamazepine and B. monnieri treatments to epileptic rats reversed the down regulated 5-HT content (pb0.01), 5-HT2C receptor binding (pb0.001) and gene expression (pb0.01) to near control level. Also, the Rotarod test confirms the motor dysfunction and recovery by B. monnieri treatment. These data suggest the neuroprotective role of B. monnieri through the upregulation of 5-HT2C receptor in epileptic rats. This has clinical significance in the management of epilepsy en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Epilepsy en_US
dc.subject 5-HT2C receptor en_US
dc.subject Cerebellum en_US
dc.subject Bacopa monnieri en_US
dc.subject Motor dysfunction en_US
dc.subject CT value en_US
dc.subject Log RQ value en_US
dc.title Down-regulation of cerebellar 5-HT2C receptors in pilocarpine-induced epilepsy in rats: Therapeutic role of Bacopa monnieri extract en_US
dc.type Working Paper en_US


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