5-HT1A AND 5-HT2C RECEPTOR GENE EXPRESSION AND FUNCTIONAL REGULATION DURING RAT HEPATOCYTE PROLIFERATION AND APOPTOSIS

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5-HT1A AND 5-HT2C RECEPTOR GENE EXPRESSION AND FUNCTIONAL REGULATION DURING RAT HEPATOCYTE PROLIFERATION AND APOPTOSIS

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dc.contributor.author Pyroja, S
dc.contributor.author Paulose, C S
dc.date.accessioned 2008-07-24T05:11:37Z
dc.date.available 2008-07-24T05:11:37Z
dc.date.issued 2002-04
dc.identifier.uri http://dyuthi.cusat.ac.in/purl/118
dc.description.abstract The work is an attempt to understand the role of 5-HT, 5-HT1A and 5-HT2C receptors in the regulation of liver cell proliferation using in vivo and in vitro models. The work also focuses on the brain serotonergic changes associated with hapatocyte proliferation and apoptosis to delineate its regulatory function. The investigation of mechanisms involving different models of hepatocyte proliferation contributes to our knowledge about serotonergic regulation of cell growth, apoptosis and carcinogenesis of liver. The study reveals that the alteration of the 5-HT1A and 5-HT2C receptor function and gene expression in the brain stem, cerebral cortex and hypothalamus play an important role in the sympathetic regulation of cell proliferation, neoplastic transformation and apoptosis. The functional balance between 5-HT1A and 5-HT2C receptor plays an important role in regulating hepatocyte proliferation, neoplastic transformation and hepatic apoptosis. The regulatory role of 5-HT1A and 5-HT2C receptor during neoplastic transformation and apoptosis could lead to possible therapeutic intervention in the treatment of cancers and have immense clinical importance. en_US
dc.language.iso en en_US
dc.publisher Department of Biotechnology, Faculty of Science en_US
dc.subject 5-HT en_US
dc.subject 5-HT2C receptor en_US
dc.subject 5-Hydroxy tryptamine en_US
dc.subject Hepatocyte proliferation en_US
dc.subject Gene expression en_US
dc.subject Apoptosis en_US
dc.subject Cell proliferation en_US
dc.subject Rat hepatocyte proliferation en_US
dc.subject 5-HT1A receptor en_US
dc.title 5-HT1A AND 5-HT2C RECEPTOR GENE EXPRESSION AND FUNCTIONAL REGULATION DURING RAT HEPATOCYTE PROLIFERATION AND APOPTOSIS en_US
dc.type Thesis en_US


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