Alex,A V; Jacob, Philip(Cochin University of Science and Technology, May , 2001)
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Abstract:
Ultrasonic is a good tool to investigate the elastic properties of crystals. It enables one to determine all the elastic constants, Poisson’s ratios, volume compressibility and bulk modulus of crystals from velocity measurements. It also enables one to demonstrate the anisotropy of elastic properties by plotting sections of the surfaces of phase velocity, slowness, group velocity, Young’s modulus and linear compressibility along the a-b, b-c and a-c planes. They also help one to understand more about phonon amplification and help to interpret various phenomena associated with ultrasonic wave propagation, thermal conductivity, phonon transport etc. Study of nonlinear optical crystals is very important from an application point of view. Hundreds of new NLO materials are synthesized to meet the requirements for various applications. Inorganic, organic and organometallic or semiorganic classes of compounds have been studied for several reasons. Semiorganic compounds have some advantages over their inorganic and inorganic counterparts with regard to their mechanical properties. High damage resistance, high melting point, good transparency and non-hygroscopy are some of the basic requirements for a material to be suitable for device fabrication. New NLO materials are being synthesized and investigation of the mechanical and elastic properties of these crystals is very important to test the suitability of these materials for technological applications
Godfrey,Louis; Jacob, Philip(Department of Physics, 1994)
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Abstract:
The thesis investigated the elastic properties and phase transitions in selected mixed sulphate crystals – Lithium Hydrazinium Sulphate [LiN2H2SO4], Lithium Ammonium Sulphate [LiNH4SO4] and Lithium Potassium Sulphate [LiKSO4] – using ultrasonic technique. The pulse echo overlap technique has been used for measuring ultrasonic velocity and its dependence on temperature along different directions with waves of longitudinal and transverse polarizations. Two major numerical techniques and the corresponding computer programs developed as part of present work are presented in this thesis. All the 9 elastic constants of LHS are determined accurately from ultrasonic measurements and applying misorientation correction refines the constants. Ultrasonic measurements are performed in LAS to determine the elastic constants and to study the low temperature phase transitions. Temperature variation studies of elastic constant of LAS are performed for 6 different modes of propagation for heating and cooling at low temperatures. All the 5 independent elastic constants of LPS is determined using ultrasonic measurements. It is concluded that LPS crystal does not undergo a phase transition near this temperature. A comparison of the three crystals studied shows that LPS has maximum number of phase transitions and LHS has the least number. It is interesting to note that LPS has the simplest formula unit among the three. There is considerable scope for the future work on these crystals and others belonging to the sulphate family.
Prabha, C; Dr.Pillai, P R S(Cochin University of Science And Technology, July 24, 2013)
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Abstract:
Underwater target localization and tracking attracts tremendous research interest due to various impediments to the estimation task caused by the noisy ocean environment. This thesis envisages the implementation of a prototype automated system for underwater target localization, tracking and classification using passive listening buoy systems and target identification techniques. An autonomous three buoy system has been developed and field trials have been conducted successfully. Inaccuracies in the localization results, due to changes in the environmental parameters, measurement errors and theoretical approximations are refined using the Kalman filter approach. Simulation studies have been conducted for the tracking of targets with different scenarios even under maneuvering situations. This system can as well be used for classifying the unknown targets by extracting the features of the noise emanations from the targets.
Description:
Department of Electronics, Cochin University of Science and Technology.
Nify, Benny; Dr.Sujatha, C H(Cochin University of Science and Technology, June , 2009)
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Abstract:
The thesis deals with a benchmark study of dissolved and sedimentary sulphur
compounds which play prominent roles in the prevailing redox conditions in the
selected sites of Cochin estuarine system. Sulphur and its analogues play prominent
roles in estuarine biochemical processes. A complete knowledge on the sulphur
involvement in these processes is restricted due to the lacking of data on the organic
sulphur compounds. Sulphate and sulphide in surface and bottom water and
Sulphate, acid volatile sulphide and total sulphur in sediments were studied and
correlated to know their interrelations in determining the redox condition of the
environment. It also characterises the sediments of the sites on the basis of total
organic carbon: total sulphur ratio. The study had attempted to decrease the
concentration levels of sulphur in the sedimentary environment by the application of
a remedial measure. Knowledge of sulphur uptake by plants from prior literatures
has prompted to use phytoremediation for decreasing the sulphur concentration.
Phytoremediation is an emerging technology that uses plants to clean up or remediate
contaminated soil, sludges, sediments, and ground water through contaminant
removal, degradation or containment. The plant selected was wheat grass since
earlier studies have shown that wheat grass is effective in remediating pollutants
particularly trace metals. So reduction in the concentration of selected trace metals
was also focussed.
Description:
Department of Chemical Oceanography, Cochin University of Science and Technology
Radhakrishnan, N; Dr.Meera Bai,M(Cochin University of Science and Technology, November 20, 2003)
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Abstract:
Studies in urban water supply system are few in the state of Kerala.
It is a little researched area. In the case of water pricing a number of studies are
available. In Kerala state, exception to Jacob John’s study on “Economics of
Public Water Supply System”, which is a case study of Trivandrum Water Supply
System in 1997, no exhaustive research work has so far come out in this field.
loreover no indepth research study has come up, so far, relating to household
ater demand analysis and the distribution system of urban piped water supply.
he proposed study is first of its kind, which focuses on the distributional and
Iailability problems of piped water supply in an urban centre in Kerala state.
Hence there is a felt need for enquiring into the sufficiency of
)table water supplied to people in urban areas and the efficiency maintained in
roviding the scarce resource and preventing its misuse by the consumers. It is in
llS backdrop that this study was undertaken and its empirical part was conducted
|Calicut city in the state of Kerala. Study is confined to the water supply system
ithe city of Calicut
Description:
Department of Applied Economics,
Cochin University of Science and Technology
Babu, K K; Dr. Beena, K S(Cochin University of Science and Technology, May , 2007)
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Abstract:
The increasing tempo of construction activity the world over creates heavy pressure
on existing land space. The quest for new and competent site often points to the needs
for improving existing sites, which are otherwise deemed unsuitable for adopting
conventional foundations. This is accomplished by ground improvement methods,
which are employed to improve the quality of soil incompetent in their natural state.
Among the construction activities, a well-connected road network is one of the basic
infrastructure requirements, which play a vital role for the fast and comfortable
movement of inter- regional traffic in countries like India.One of the innovative ground improvement techniques practised all over the world is
the use of geosynthetics, which include geotextiles, geomembranes, geogrids, etc .
They offer the advantages such as space saving, enviromnental sensitivity, material
availability, technical superiority, higher cost savings, less construction time, etc .
Because of its fundamental properties, such as tensile strength, filtering and water
permeability, a geotextile inserted between the base material and sub grade can
function as reinforcement, a filter medium, a separation layer and as a drainage
medium. Though polymeric geotextiles are used in abundant quantities, the use of
natural geotextiles (like coir, jute, etc.) has yet to get momentum. This is primarily
due to the lack of research work on natural geotextilcs for ground improvement,
particularly in the areas of un paved roads. Coir geotextiles are best suited for low cost
applications because of its availability at low prices compared to its synthetic
counterparts. The proper utilisation of coir geotextilcs in various applications demands large quantities of the product, which in turn can create a boom in the coir
industry. The present study aims at exploring the possibilities of utilising coir
geotextiles for unpaved roads and embankments.The properties of coir geotextiles used have been evaluated. The properties studied
include mass per unit area, puncture resistance, tensile strength, secant modulus, etc .
The interfacial friction between soils and three types of coir geotextiles used was also
evaluated. It was found that though the parameters evaluated for coir geotextiles have
low values compared to polymeric geotextiles, the former are sufficient for use in
unpaved roads and embankments. The frictional characteristics of coir geotextile - soil
interfaces are extremely good and satisfy the condition set by the International
Geosynthetic Society for varied applications.The performance of coir geotextiles reinforced subgrade was studied by conducting
California Bearing Ratio (CBR) tests. Studies were made with coir geotextiles placed
at different levels and also in multiple layers. The results have shown that the coir
geotextile enhances the subgrade strength. A regression analysis was perfonned and a
mathematical model was developed to predict the CBR of the coir geotextile
reinforced subgrade soil as a function of the soil properties, coir geotextile properties,
and placement depth of reinforcement.The effects of coir geotextiles on bearing capacity were studied by perfonning plate
load tests in a test tan1e This helped to understand the functioning of geotextile as
reinforcement in unpaved roads and embankments. The perfonnance of different
types of coir geotextiles with respect to the placement depth in dry and saturated
conditions was studied. The results revealed that the bearing capacity of coir-reinforced soil is increasing irrespective of the type of coir geotextiles and saturation
condition.The rut behaviour of unreinforced and coir reinforced unpaved road sections were
compared by conducting model static load tests in a test tank and also under repetitive
loads in a wheel track test facility. The results showed that coir geotextiles could
fulfill the functions as reinforcement and as a separator, both under static and
repetitive loads. The rut depth was very much reduced whik placing coir geotextiles
in between sub grade and sub base.In order to study the use of Coir geotextiles in improving the settlement
characteristics, two types of prefabricated COlf geotextile vertical drains were
developed and their time - settlement behaviour were studied. Three different
dispositions were tried. It was found that the coir geotextile drains were very effective
in reducing consolidation time due to radial drainage. The circular drains in triangular
disposition gave maximum beneficial effect.In long run, the degradation of coir geotextile is expected, which results in a soil -
fibre matrix. Hence, studies pertaining to strength and compressibility characteristics
of soil - coir fibre composites were conducted. Experiments were done using coir
fibres having different aspect ratios and in different proportions. The results revealed
that the strength of the soil was increased by 150% to 200% when mixed with 2% of
fibre having approximately 12mm length, at all compaction conditions. Also, the
coefficient of consolidation increased and compression index decreased with the
addition of coir fibre.Typical design charts were prepared for the design of coir geotextile reinforced
unpaved roads. Some illustrative examples are also given. The results demonstrated that a considerable saving in subase / base thickness can he achieved with the use of
eoir geotextiles, which in turn, would save large quantities of natural aggregates.
Description:
Division of Civil Engineering,
Cochin University of Science and Technology
Anil, Loveson; Rajathy, Sivalingam(Cochin University of Science And Technology, August , 2014)
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Abstract:
One of the objectives of the current investigation was to evaluate the effectiveness of Spirodela polyrhiza to remove heavy metals and other contaminants from the water samples collected from wetland sites of Eloor and Kannamaly under controlled conditions .The results obtained from the current study suggest that the test material S. polyrrhiza should be used in the biomonitoring and phytoremediation of municipal, agricultural and industrial effluents because of their simplicity, sensitivity and cost-effectiveness. The study throws light on the potential of this plant which can be used as an assessment tool in two diverse wetland in Ernakulum district. The results show the usefulness of combining physicochemical analysis with bioassays as such approach ensures better understanding of the toxicity of chemical pollutants and their influence on plant health. The results shows the suitability of Spirodela plant for surface water quality assessment as all selected parameters showed consistency with respect to water samples collected over a 3-monitoring periods. Similarly the relationship between the change in exposure period (2, 4 and 8 days) with the parameters were also studied in detail. Spirodela are consistent test material as they are homogeneous plant material; due to predominantly vegetative reproduction. New fronds are formed by clonal propagation thus, producing a population of genetically homogeneous plants. The result is small variability between treated individuals. It has been observed that phytoremediation of water samples collected from Eloor and Kannamaly using the floating plant system is a predominant method which is economic to construct, requires little maintenance and eco friendly.
Ganapathy, Rajendran; Dr.Kuriakose, A P(Cochin University of Science and Technology, August 21, 1995)
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Abstract:
The thesis consists of seven chapters. The first
chapter is a general introduction on rice by-products,
their composition and utilization at present. The
different milling processes adopted in paddy and the major
by-products obtained from these processes viz. rice husk,
rice bran, rice bran oil and rice husk ash are described.
The physical properties and chemical composition of the
rice husk and its general uses are given in detail. The
chemical composition of the rice bran and its separation
from paddy is also included. The details of solvent
extraction process used for obtaining rice bran oil and
also its chemical constitution is discussed in this
chapter. Also described is the preparation and the
different uses of rice husk ash. A literature survey is
also done on the utilization of rice by-products in rubber
and plastics as on today. The scope and objectives of the
present study is also included at the end of this chapter.
Description:
Department of
Polymer Science and Rubber Technology, Cochin University of
Science and Technology
Thomas,C J; Dr.Ramachandra, Poduval P(Cochin University of Science And Technology, April , 1997)
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Abstract:
The present study is on
value orientation of professional students•and as such the theoretical value is
inherent and implied. Variation on this value is likely to be limited among
the subjects.
The relevance of the present study is with particular reference, to
management as a profession. In organisational settings motivation plays an
important role. According to McClelland's theory of needs, achievement,
power, and affiliation are the three important needs that help in understanding
motivation. Achieve~ent need may be defined as the drive to excel, to achieve
in relation to a set of standards, and to strive to succeed. Some people have a
compelling drive to succeed. They have a desire to do something better or
more efficiently than it has been done before. McClelland found that high
achievers differentiate themselves from others by their desire to do things
. better. Considering this fact, 'achievement' is included as one of the values
for the study
Description:
School of Management Studies, Cochin University of Science and Technology
Radhika, T; Dr.Mohanan, P V; Dr.Sugunan, S(Cochin University of Science and Technology, November 23, 2005)
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Abstract:
The selective oxidation of alkylaromatics is one of the main processes since the reaction products are important as intermediates in numerous industrial organic chemicals. Side-chain oxidation of alkyl aromatic compounds catalyzed by heterogeneous catalysts using cleaner peroxide oxidants is an especially attractive goal since classical synthetic laboratory procedures preferably use permanganate or acid dichromate as stoichiometric oxidants. In spite of many studies, there are very few which use hydrogen peroxide as a source of oxygen in the C-H activation of alkanes. Eflective utilization of ethylbenzene, available in the xylene stream of the petrochemical industry to more value added products is a promising one in chemical industry. The oxidation products of ethylbenzene are widely employed as intermediates in organic, steroid and resin synthesis.
Description:
Department of Chemistry, Cochin University of Science andTechnology,
Surekhamol, I S; Dr.Bright Singh,I S(Cochin University of Science and Technology, November , 2012)
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Abstract:
Aquaculture is a global industry providing food and employment thereby contributing to the economy. For the sustenance of aquaculture, disease management is a major requirement. Among the bacterial pathogens Vibrio harveyi remains to be the major one especially in shrimp culture systems. Rapid
and mass mortality of shrimp larvae due to Vibrio harveyi infection is well known, and the pathogen causes serious economic losses in grow out systems as well. It suggests that a well defined management strategy has to be built up to protect the crop from Vibrio harveyi infection in aquaculture systems. Antibiotics have been the choice for quite some times which led to residues in meat and development of multidrug resistant bacteria which invited ban on their application. In this context several alternate options have been thought off such as probiotics, immunostimulants and vaccines. Phage therapy is yet another option. Phages being natural parasites of bacteria and are abundant in aquatic environments their application to control bacterial pathogens in aquaculture has commendable potential in lieu of antibiotics. For that matter the therapeutic effect of phages has been proven in several antibiotic resistant pathogens inclusive of Vibrio harveyi.
Description:
National Centre for Aquatic Animal
Health, School of Environmental Studies, Cochin University of Science and Technology
Anil Kumar, R; Dr.George, Varghese K(Cochin University Of Science And Technology, November , 2012)
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Abstract:
This study analyses the socio-economic backgrounds and entrepreneurial
profiles of the students and pass outs of the Vocational Higher Secondary
Education in Kerala and the academic achievements of the Vocational Higher
Secondary students and pass outs in Kerala in terms of their performance in the
examinations. The study also analyses the quality and availability of the various
training and support facilities of the Vocational Higher Secondary Schools in
Kerala, nature and rate of employment and higher studies among the pass outs
of the Vocational Higher Secondary Education in Kerala and the awareness of
students, pass outs, teachers and principals regarding the goals and objectives,
mode of implementation, apprenticeship training and higher study and
employment opportunities of the programme of the Vocational Higher
Secondary Education in Kerala.
Description:
School of Management Studies,
Cochin University of Science and Technology
Laina, A L; Dr.Girish Kumar, K(Cochin University Of Science And Technology, April , 2013)
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Abstract:
Electrochemical sensors are increasingly being investigated to perform
measurements for single or multiple analytes. Demanded by modern medical
diagnosis, advances in microfabrication technology have led to the development
of fast, sensitive and selective electrochemical sensors for drug analysis.
Electrochemical sensors for the measurement of analytes of interest in clinical
chemistry are ideally suited for these applications, due to their high sensitivity
and selectivity, simple-to-operate, rapid response time and low-cost.
As part of the present investigations eight voltammetric sensors have been
fabricated for six drugs such as PAM Chloride, Tamsulosin Hydrochloride,
Hesperidin Methyl Chalcone, Guaiphenesin, Cephalexin and Amoxicillin
trihydrate. The modification techniques adopted as part of the present work
include multiwalled carbon nanotube (MWNT) based modifications,
electropolymerization, gold nanoparticle (AuNP) based modifications and
platinum nanoparticle (PtNP) based modifications.
The thesis is divided into nine chapters
Description:
Department of Applied Chemistry
Cochin University of Science and Technology
Rajan, Varghese K E; Dr.Chandrasekharan, N S(Cochin University of Science And Technology, November , 1985)
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Abstract:
India is on the threshold of industrial and economic
development. The growth would be retarded if harmonious
employer-employee relations are not maintained. 'Wages'
plays a fundamental role in establishing this relationship.
However, much controversy in the industrial sphere revolves
round the question of wages. Though formerly the laissez
faire doctrine prevailed, with the emergence of the welfare
state ideology, notions of national economy and social
justice gained prominence. The problem of wages has became
one with social, political, economic, psychological and
legal dimensions.
Formulation of a proper wage policy is thus a riddle.
Realities of the present have to be fused with perspectives
about the future. With due recognition of all significant
factors, a proper balance has to be struck, which should
be the hard core of any wage policy. This study emphasises
the need for a wage policy which may meet the requirements
of rapid economic growth and stable industrial relations.
The study also indicates the proper bases for the promotien
of such a policy.
Description:
School of Legal Studies, Cochin University of Science And Technology
Ushakumary, E R; Dr.Madhu, G(Cochin University Of Science And Technology, April , 2013)
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Abstract:
Heavy metals are major toxic pollutants with severe health effects on
humans. They are released into the environment from a variety of industrial
activities. Cadmium, lead, zinc, chromium and copper are the most toxic
metals of widespread use in industries such as tanning, electroplating,
electronic equipment manufacturing and chemical processing plants. Heavy
metals contribute to a variety of adverse health environmental effects due to
their acute and chronic exposure through air, water and food chain.
Conventional treatment methods of metal removal are often limited by their
cost and ineffectiveness at low concentrations. Adsorption, the use of
inactivated biomass as adsorbents offers an attractive potential alternative to
their conventional methods. Mango peel and Alisma plantago aquatica are
naturally occurring and abundant biomass can offer an economical solution for
metal removal.The Cd(II), Pb(II), Zn(II), Cr(III) and Cu(II) adsorption by milled
adsorbents of mango peel and Alisma plantago aquatica were evaluated in
batches.
Description:
School of
Engineering, Cochin University of Science and Technology
Madhusoodanan,P; Dr.Sharma,G S(Cochin University of Science and Technology, October , 1985)
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Abstract:
At intermediate depths of the Arabian Sea, the circulation and characteristics of water are more
influenced by the high saline waters from the north and low saline waters from the south of equator. The interaction of these waters which greatly differ in characteristics is less understood compared to that at the upper layers. An understanding of the nature of the intermediate waters is of vital importance not only because of the unusual characteristics of the waters but also due to the influx of the different water masses from the neighbouring Red Sea and Persian Gulf. Hence, in the present investigation, it is proposed to study the water characteristics and current structure of the intermediate waters in the Arabian Sea through the distribution of the water properties on the isanosteric surfaces of 100, 80, 60 and 4O—cl/t, vertical sections, and scatter diagrams An attempt is also made to present the potential vorticity between different steric levels to understand the circulation and mixing processes. Data collected during and subsequent to International Indian Ocean Expedition (IIOE) are used for this study. The thesis has been divided into six chapters with further sub divisions
Peter, Varkey K; Dr.Sivasankara Pillai, V N(Cochin University of Science and Technology, December , 2002)
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Abstract:
The Kerala Water Authority requested the School of Environmental Studies to
carry out investigations on the mechanism of sporadic mobilization of iron and
odour in the raw water drawn to the drinking water treatment plant. The
currently used treatment process failed to remove iron completely. This led to
problems in the filter and complaints of taste and colour due to iron in the
finished water. The sporadic nature of the problem itself made the trouble
shooting difficult.
The problem was looked in from three points of view.
1. Influence of environmental (climatic) conditions on the dynamics of
the relevant basin of the reservoir.
2. Influence of the physical dynamics on the physico — chemical quality
of water.
3. Identification of cost-effective treatment processes to suit the existing
plant.
Since the problem emerged only during the post- monsoon to pre-monsoon
months, a related problem was investigated, namely, influence of anions on
the oxidation of Fe(II) in natural waters by air. This is presented in Part II of
the dissertation.
Description:
School of
Environmental Studies, Cochin University of Science and Technology
Soman, C K; Dr.Jose, Kallarackal(Cochin University of Science And Technology, May , 1997)
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Abstract:
Investigations on the water relations and gas exchange of/tcacia aun'culiji_2rmis
were carried out in natural and controlled environments. The experiments were
performed in both seedlings and five year old trees. Different sets of experiments
were conducted in Acacia plantations, at Kothachira, Palakkad District and in
.seedlings, at KFRI campus nursery mainly during the summer months. Investigations
were also extended to seedlings of A.mangium, Aaulacocarpa and /Lholocericea,
which are also phyllodinous species with the intention of comparing their physiology
with Acacia auriculifomus.
Potted seedlings of four species of Acacia viz., A. auriculi/E)/7r:i.r, /I.
aulacocarpa, A. holocericea and A. mangium were used for the study.
Measurements of relative water content (RWC), water potential, photosynthetic rate,
transpiration, stomatal conductance, water use efficiency etc. of phyllodes were
measured diumally in plants subjected to three stress conditions namely, drought,
salinity and flooding
Kurian,N P; Dr.Baba, M(Cochin University Of Science And Technology, July 2, 1987)
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Abstract:
There are basically two methods for prediction of
shallow water waves, viz. the graphical method and the
numerical method. The numerical methods are being widely
used, now—a—days, because they are fast, accurate and are
especially useful when the prediction over a large spatial
frame is required. Practically little has been done on the
development of numerical models for the prediction of height
and spectral transformation of waves as applicable to our
coasts. Synchronized deep and shallow water wave measurements
which are essential for study of wave transformation are
very much lacking for our coasts. Under these
circumstances, a comprehensive study of the wave
transformation in the shallow waters of our coast was felt
very important and is undertaken in the present
investigation.
Description:
Centre for Earth Science
Studies,Cochin University Of Science And Technology
Rajesh, J; Dr.Mohan Kumar, K(Cochin University of Science and Technology, August 25, 2009)
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Abstract:
The Doctoral thesis focuses on the factors that influence the weather and climate
over Peninsular Indias. The first chapter provides a general introduction about the climatic features over peninsular India, various factors dealt in subsequent chapters, such as solar forcing on climate, SST variability in the northern Indian Ocean and its influence on Indian monsoon, moisture content of the atmosphere and its importance in the climate system, empirical formulation of regression forecast of climate and some aspects of regional climate modeling. Chapter 2 deals with the variability in the vertically integrated moisture (VIM) over Peninsular India on various time scales. The third Chapter discusses the influence of solar activity in the low frequency variability in the rainfall of Peninsular India. The study also investigates the influence of solar activity on the horizontal and vertical components of wind and the difference in the forcing before and after the so-called regime shift in the climate system before and after mid-1970s.In Chapter 4 on Peninsular Indian Rainfall and its association with meteorological and oceanic parameters over adjoining oceanic region, a linear regression model was developed and tested for the seasonal rainfall prediction of Peninsular India.
Description:
Department
of Atmospheric Sciences, Cochin University of Science and Technology
Manjusha, M; Dr.Bright Singh,I S(School of Environmental Studies,Faculty of Marine Sciences, 2003)
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Abstract:
The present study is the first comprehensive approach towards histopathology of White Spot Syndrome Virus (WSSV) in Penaeus indicus. WSSV could be demonstrated in the nuclei of all tissues, except those of midgut, subjected of electron microscopic observation. They were the nuclei of gill, foregut, heart, hepatopancreatic connective tissue, hindgut, nerve and dorsal aorta. A comparison was made between the electron microscopic and histopathological observations and a greater degree of correlation between the two in depicting the severity of the infection of the infection was unraveled. The study also illustrated variations in response and susceptibility of various tissues to WSSV infection. Accordingly, out of the tissues investigated, gill, foregut, hindgut and dorsal aorta exhibited advanced viral multiplication than the other tissues such as heart, midgut, nerve and hepatopancreas. Even though hepatocytes were not infected the connective tissue nuclei were packed with virions.
Smijin, Soman K; Dr. Paulose, C S(Cochin University of Science and Technology, July 2, 2012)
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Abstract:
The onset of spontaneous seizures triggers a cascade of molecular and cellular events that eventually leads to neuronal injury and cognitive decline. The present study investigated the effect of Withania somnifera (WS) root extract and Withanolide A (WA) in restoring behavioural deficit by inhibiting oxidative stress induced alteration in glutamergic neurotransmission. The subdued performance in
behavioural tests shows impaired motor coordination and memory. Histopathological investigations revealed significant neuronal loss in hippocampus of epileptic rats indicating glutamate mediated excitotoxicity. The treatment with WS and WA restored behavioural deficit and ameliorated neuronal loss. An altered redox homeostasis leading to oxidative stress is a hallmark of TLE. The antioxidant potential was afflicted in epileptic rats, evident from altered activity of SOD and CAT, down regulation of SOD and GPX expression and enhanced lipid peroxidation. The antioxidant property of WS and WA restored altered antioxidant capacity. Alteration in GDH activity and down regulation of GLAST expression resulted in enhanced glutamate content in the brain regions. The metabolism of glutamate was altered in the form of down regulated GAD expression. The alteration in synthesis, transport and metabolism resulted in further increase of the glutamate concentration at the synapse leading to glutamate mediated excitotoxicity. The decreased NMDA and AMPA receptor binding and down
regulated NMDA R1, NMDA 2B and AMPA (GluR2) mRNA expression indicated altered glutamergic receptor function. The treatment with WS and WA reversed altered glutamergic receptor function, synthesis, transport and metabolism. The enhanced levels of second messenger IP3 responsible for Ca2+ mediated toxicity was reversed after treatment with WS and WA. Neurotoxics concentration of glutamate resulted in up regulation of pro apoptotic factors Bax and Caspase 8 and down regulation of anti apoptotic factor Akt resulting in neuronal death. The treatment with WS and WA resulted in activation of Akt and down regulation of Bax and caspase 8 leading to blocking of apoptotic pathway.
The treatment with WS and WA resulted in reduced seizure frequency and amelioration of associated alterations suggesting the therapeutic role of Withania somnifera in temporal lobe epilepsy
Description:
Department of Biotechnology, Cochin University of Science and Technology
Celine, Scaria K; Dr.George, C M(Cochin University of Science And Technology, July , 1985)
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Abstract:
The corporate views on wives roles and their subsequent involvement in their husbands career seem to be quiet surprising .Even though the corporate magnates are aware of wives influence on husbands professional advancements they seldom give credit to this factor. Again it may be an eye opener for the corporations which hardly take note of the executives wives their likes or dislikes, their expectations or frustrations. They are to understand that man in his totality and decisions affecting his family have to be taken seriously. More over they should respect the right of the wives by understanding the exact role played by them. Thus this study is to understand the roles and contributions of executives wives to the success of their husbands in their professions. The study tries to minimize the gap between the corporations and the wives ,and also to make the wives aware of their peculiar role in the career advancement of their executive husbands.
Description:
School of management studies, Cochin University of Science And Technology