Radhakrishna Pillai, S; Dr.Sukumaran Nair, M K(Cochin University of Science And Technology, May , 1991)
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Abstract:
The contemporary explanations and discussions of
the relationship between medicine and health, and society
centre around assumptions that can be broadly classified
into three setsl.
The first set considers health and illness as
predominantly ‘biological’ and therefore, having nothing to
do with the social and economic environment in which it
occurs. The struggle to combat illness therefore, lies
entirely within the purview of modern medicine which is
neutral to economic or social change.
The second considers practice of medicine as a
natural science. It allows the doctor to separate himself
from his subject matter, the patient, in the samelway as the
natural scientist is assumed to separate himself from his subject matter, the natural world. As a 'science' and with
the scientific method, it can produce unchallengable and
autonomous body of knowledge which is free from the wider
social and economic context.
The third, different from the above, recognises
the relationship between health, medicine and society.
Social and environmental aspects as determinants of illness
or of health comes to sharp focus here and it assigns to
medicine the status of a mediator, the only viable mediator,
between people and diseases. In this scheme of things the
usefulness of medicine is unquestionable but the problem
lies in not having enough of it to go arounds.
Description:
Department of Applied Economics, Cochin University of Science and Technology
Nandha, B; Dr.Mary,Joseph(Cochin University of Science and Technology, September 3, 1998)
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Abstract:
In general the behavioural sciences have contributed very little to filariasis research.Man's actions in creating vector breeding sites have been noted and discussed frequently inthe frlariasis literature. but virtually no systematic studies of these fonns of behavior have been undertaken (Dunn. 1979). Human behavioural observations and inquires into values and attitudes atfecting behavior that inhibits or promotes vector breeding are essential if any progress is to be made in developing self help programmes of vector control. Therefore, a systematic study on the socio-economic aspect of the community is warranted before undertaking any control programme against filariasis. In view of this the present study has been carried out which reveals the knowledge, attitude and practice concerning the causation, transmission, treatment and control of the disease. Socio economic factors that influence the creation and maintenance of vector breeding habitats were identified. characterization and ranking of these sociological factors will be helpful in identifying the determinants of human behavioural changes towards the containment of the disease- Information on the existing indigenous perception of the disease and the factors that hinder the control will be useful in developing a sound strategy from the human angle, which can be put to practical use.
Description:
School of Management Studies, Cochin University of Science
and Technology
Emmanuel, Kadudose A; Dr.Sankaranarayanan, K C(Cochin University of Science and Technology, August 9, 1989)
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Abstract:
This thesis Entitled Socio-Economic Survey of a Specific village.For the purpose of analysis the thesis is divided into nine chapters. The first chapter introduces the subject of study and explains the significance of the study.It also provides the profile of the village. Chapter two deals with the different aspects of agriculture in the village.Chapter three discusses the problems of industrialisation in the Village. Chapter four is on village administration. It elaborates on the services rendered by government machinery in facilitating the development of agriculture and industry in the village.Chapter five explains the ways and means of marketing of village produce, both industrial and agricultural origin. It also explains the relevance of intra village connections in facilitating marketing.Chapter seven provides information regarding the income and expenditure pattern of the village.Chapter eight is on village social life. It explains the social life of the villagers, including religious
Description:
Department of Applied Economics, Cochin
University of Science and Technology
Reena, Murali; Dr David Peter(Cochin University of Science and Technology, February 15, 2016)
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Abstract:
Post-transcriptional gene silencing by RNA interference is
mediated by small interfering RNA called siRNA. This gene
silencing mechanism can be exploited therapeutically to a wide
variety of disease-associated targets, especially in AIDS,
neurodegenerative diseases, cholesterol and cancer on mice with the
hope of extending these approaches to treat humans. Over the recent
past, a significant amount of work has been undertaken to understand
the gene silencing mediated by exogenous siRNA. The design of
efficient exogenous siRNA sequences is challenging because of many
issues related to siRNA. While designing efficient siRNA, target
mRNAs must be selected such that their corresponding siRNAs are
likely to be efficient against that target and unlikely to accidentally
silence other transcripts due to sequence similarity. So before doing
gene silencing by siRNAs, it is essential to analyze their off-target
effects in addition to their inhibition efficiency against a particular
target. Hence designing exogenous siRNA with good knock-down
efficiency and target specificity is an area of concern to be addressed.
Some methods have been developed already by considering both
inhibition efficiency and off-target possibility of siRNA against agene. Out of these methods, only a few have achieved good inhibition
efficiency, specificity and sensitivity.
The main focus of this thesis is to develop computational
methods to optimize the efficiency of siRNA in terms of “inhibition
capacity and off-target possibility” against target mRNAs with
improved efficacy, which may be useful in the area of gene silencing
and drug design for tumor development. This study aims to
investigate the currently available siRNA prediction approaches and
to devise a better computational approach to tackle the problem of
siRNA efficacy by inhibition capacity and off-target possibility. The
strength and limitations of the available approaches are investigated
and taken into consideration for making improved solution. Thus the
approaches proposed in this study extend some of the good scoring
previous state of the art techniques by incorporating machine learning
and statistical approaches and thermodynamic features like whole
stacking energy to improve the prediction accuracy, inhibition
efficiency, sensitivity and specificity. Here, we propose one Support
Vector Machine (SVM) model, and two Artificial Neural Network
(ANN) models for siRNA efficiency prediction. In SVM model, the
classification property is used to classify whether the siRNA is
efficient or inefficient in silencing a target gene. The first ANNmodel, named siRNA Designer, is used for optimizing the inhibition
efficiency of siRNA against target genes. The second ANN model,
named Optimized siRNA Designer, OpsiD, produces efficient
siRNAs with high inhibition efficiency to degrade target genes with
improved sensitivity-specificity, and identifies the off-target knockdown
possibility of siRNA against non-target genes. The models are
trained and tested against a large data set of siRNA sequences. The
validations are conducted using Pearson Correlation Coefficient,
Mathews Correlation Coefficient, Receiver Operating Characteristic
analysis, Accuracy of prediction, Sensitivity and Specificity.
It is found that the approach, OpsiD, is capable of predicting
the inhibition capacity of siRNA against a target mRNA with
improved results over the state of the art techniques. Also we are able
to understand the influence of whole stacking energy on efficiency of
siRNA. The model is further improved by including the ability to
identify the “off-target possibility” of predicted siRNA on non-target
genes. Thus the proposed model, OpsiD, can predict optimized
siRNA by considering both “inhibition efficiency on target genes and
off-target possibility on non-target genes”, with improved inhibition
efficiency, specificity and sensitivity. Since we have taken efforts to
optimize the siRNA efficacy in terms of “inhibition efficiency and offtarget possibility”, we hope that the risk of “off-target effect” while
doing gene silencing in various bioinformatics fields can be
overcome to a great extent. These findings may provide new insights
into cancer diagnosis, prognosis and therapy by gene silencing. The
approach may be found useful for designing exogenous siRNA for
therapeutic applications and gene silencing techniques in different
areas of bioinformatics.
Jayasankar, M; Dr.Warrier, K G K(National Institute for Interdisciplinary Science and Technology, December , 2009)
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Abstract:
The thesis entitled "Sol-Gel Alumina Nano Composites for
Functional Applications" investigate sol-gel methods of synthesis of alumina
nanocomposites special reference to alumina-aluminium titanate and alumina-lanthanum
phosphate composites. The functional properties such as thermal
expansion coefficient and thermal shock resistance, machinability of composites as well as thermal protection are highlighted in addition to novel
approach in synthesis of composites.A general introduction of alumina matrix composites materials,
followed by brief coverage of alumina-aluminium titanate and alumina-lanthanum
phosphate composites is highlight of the first chapter. The second
chapter deals with the sol-gel synthesis of aluminium titanate and alumina-aluminium
titanate composite. The synthesis of machinable substrate, based on
alumina and lanthanum phosphate forms the basis of the third chapter. The
fourth chapter describes the sol-gel coating of mullite on SiC substrate for the
possible gas filtration application.
Sankar, Sasidharan; Dr K.G.K Warrier(Cochin University of Science and Technology, January 16, 2015)
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Abstract:
Lanthanum phosphate is one among the lanthanide family of “Rare Earths” following the periodic table of elements. Known under the generic name, Monazite, the rare earth phosphates have melting points above 1900 °C, high thermal phase stability, low thermal conductivity and thermal expansion coefficient similar to some of the high temperature oxides like alumina and zirconia.
Smitha, Sasidharan; Dr.Warrier, K G K(Cochin University of Science & Technology, July , 2009)
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Abstract:
The thesis covers a systematic investigation on the synthesis of
silica aerogels and microspheres with tailored porosity, at ambient conditions by
varying the experimental parameters as well as using organic templates.
Organically modified silica-gelatin and silica-chitosan hybrids were developed for
the first time using alkylalkoxysilanes such as MTMS and VTMS. Application of
novel silica-biopolymer antiwetting coatings on different substrates such as glass,
leather and textile is also demonstrated in the thesis.
Sibu,C P; K G K Warrier(CSIR, FACULTY OF SCIENCE, 2004)
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Abstract:
In the present work Titania bulk powders and coatings were prepared by subjecting titanium isopropoxide solution to a controlled hydrolysis-condensation process. The powders were characterized using techniques such as FTIR for their chemical interactions, TG-DTA for the thermal decomposition features, XRD for the phase assemblage, BET specific surface area analysis for the textural features. The study discusses the preparation methods and the characterization techniques employed and a detailed discussion on the physico-chemical characterization of the prepared systems. The influence of dopants and leaching on the physico-chemical properties as well as their influence on photo activity is also included. The structural/functional coatings of different Titania compositions includes in this study. Coatings on pre-treated glass surfaces with the best compositions prepared showed 90 % transmittance in the visible region.
Sajan, P; Dr. M. Junaid Bushiri(Cochin University of Science and Technology, June 5, 2016)
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Abstract:
The research on nanocrystalline materials have been of great interest for
more than 20 years due to its fundamental properties as well as development of
technology based on it. Non-toxic semiconducting nanocrystals are important
materials with wide range of applications in the areas of biotechnology, medicine,
bio-optics and for the fabrication light emitting and harvesting devices. Majority of
the II-VI semiconductors possess wide band gap along with high iconicity and are
important materials for optoelectronic devices operating under the UV excitation
sources. Among the II-VI semiconductors, ZnS is a material with good optical
transmission in the visible region with large exciton binding energy of about 40
meV. ZnS usually crystallizes in cubic form which is zinc blende or sphalerite and
its hexagonal form is in wurtzite phase. The cubic sphalerite phase of ZnS has a
band gap of 3.68 eV whereas the hexagonal (wurtzite) phase has a band gap of 3.77
eV. Moreover, ZnS is a good host lattice phosphor for photonic applications and
electroluminescent devices because of its wide band gap.
The present thesis deals with the synthesis and photoluminescence studies
of micro and nanostructured ZnS by hydrothermal and solvo-hydrothermal method.
Thesis is also focused on bioimaging application of these materials.
Syed Aftab, Husain Rizvi; Dr.Wazir, Hasan Abdi(Cochin University of Science And Technology, March , 1984)
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Abstract:
This thesis is an attempt to throw light on the works
of some Indian Mathematicians who wrote in Arabic or
persian In the Introductory Chapter on outline of
general history of Mathematics during the eighteenth
Bnd nineteenth century has been sketched. During that
period there were two streams of Mathematical activity.
On one side many eminent scholers, who wrote in Sanskrit,
.he l d the field as before without being much influenced
by other sources. On the other side there were scholars
whose writings were based on Arabic and Persian text
but who occasionally drew upon other sources also.
Description:
Department of Mathematics and Statistics, Cochin University of Science and Technology