http://dyuthi.cusat.ac.in:80/xmlui/handle/purl/693 Mon, 20 May 2013 00:30:48 GMT 2013-05-20T00:30:48Z http://dyuthi.cusat.ac.in:80/xmlui/handle/purl/2979 Synthesis, characterization and kinetic studies on complex formed between amantadine hydrochloride and sodium molybdate at physiological pH Sridevi, N; Yusuff, K K Mohammed The title reaction was undertaken to establish the interaction between amantadine and molybdate at physiological pH. Identical FTIR spectra, TG-DTA curves and CHN data of the complexes formed from three solutions at pH 1.5, 7.4 and 8.0 indicate that the same complex was formed at all the three pHs. The FTIR spectrum shows shift in peaks corresponding to primary amino group of the drug due to coordination to molybdate. An octahedral geometry is assigned to the complex. The kinetics of the complexation has been studied at low concentrations of the reactants using UV-visible spectrophotometry. At pH 7.4, the initial rate varies linearly with [molybdate]. A plot of initial rate versus [drug] is linear passing through origin. These results indicate that the drug and molybdate react at pH 7.4 even at low concentrations. At pH 1.5, the rate increases linearly with increase in [drug] but decreases with [molybdate]. The effect of pH and ionic strength on the rate of the reaction has also been studied. A suitable mechanism has been proposed for the reaction. Reaction between the drug and molybdate even at low concentrations and the fact that the amino group of amantadine required to be free for its function as antiviral, is bound to molybdate in the complex suggests that simultaneous administration of the drug and molybdate supplements should be avoided. Tue, 01 Jan 2008 00:00:00 GMT http://dyuthi.cusat.ac.in:80/xmlui/handle/purl/2979 2008-01-01T00:00:00Z http://dyuthi.cusat.ac.in:80/xmlui/handle/purl/1972 Organometallic Hydroxides of Transition Elements Mohammed Yusuff, K K; Roesky, Herbert W; Singh, Sanjay; Maguire, John A; Hosmane, Narayan S Sun, 01 Jan 2006 00:00:00 GMT http://dyuthi.cusat.ac.in:80/xmlui/handle/purl/1972 2006-01-01T00:00:00Z http://dyuthi.cusat.ac.in:80/xmlui/handle/purl/1971 Determination of the nature of the diperiodatocuprate(III) species in aqueous alkaline medium through a kinetic and mechanistic study on the oxidation of iodide ion Mohammed Yusuff, K K; Sridevi, Nadimpall; Jelaja, Padmavathy The nature of the diperiodatocuprate(III) (DPC) species present in aqueous alkaline medium has been investigated by a kinetic and mechanistic study on the oxidation of iodide by DPC. The reaction kinetics were studied over the 1.0 ´ 10)3±0.1 mol dm)3 alkali range. The reaction order with respect to DPC, as well as iodide, was found to be unity when [DPC] [I)]. In the 1.0 ´ 10)3±1.0 ´ 10)2 mol dm)3 alkali region, the rate decreased with increase in the alkali concentration and a plot of the pseudo-®rst order rate constant, k versus 1/[OH)] was linear. Above 5.0 ´ 10)2 mol dm)3, a plot of k versus [OH)] was also linear with a non-zero intercept. An increase in ionic strength of the reaction mixtures showed no e ect on k at low alkali concentrations, whereas at high concentrations an increase in ionic strength leads to an increase in k. A plot of 1/k versus [periodate] was linear with an intercept in both alkali ranges. Iodine was found to accelerate the reaction at the three di erent alkali concentrations employed. The observed results indicated the following equilibria for DPC. Thu, 20 Jul 2000 00:00:00 GMT http://dyuthi.cusat.ac.in:80/xmlui/handle/purl/1971 2000-07-20T00:00:00Z http://dyuthi.cusat.ac.in:80/xmlui/handle/purl/1970 Cobalt (II), Nickel (II), and Copper (II) Complexes of Polystyrene-Supported Schiff Bases Mohammed Yusuff, K K; Suja, N R Two novel polystyrene-supported Schiff bases, PSOPD and PSHQAD, were synthesized. A polymerbound aldehyde was condensed with o-phenylenediamine to prepare the Schiff base PSOPD, and a polymer-bound amine was condensed with 3-hydroxyquinoxaline-2-carboxaldehyde to prepare the Schiff base PSHQAD. This article addresses the study of cobalt (II), nickel (II), and copper (II) complexes of these polymer-bound Schiff bases. All the complexes were characterized, and the probable geometry was suggested using elemental analysis, diffuse reflectance ultraviolet, Fourier transform infrared spectroscopy, thermal studies, surface area studies, and magnetic measurements. Sun, 10 Aug 2003 00:00:00 GMT http://dyuthi.cusat.ac.in:80/xmlui/handle/purl/1970 2003-08-10T00:00:00Z